TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status.
TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status.
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TP53 密码子 72 多态性和膀胱癌风险：荟萃分析并强调肿瘤或吸烟状况的作用
DOI：
10.7150/jca.26264
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发表时间：
2018
影响因子：
3.9
通讯作者：
Song N
中科院分区：
文献类型：
--
作者：
Zhang L;Wang Y;Qin Z;Li R;Cong R;Ji C;Meng X;Wang Y;Xia J;Song N
背景：各种研究探讨了TP53密码子72多态与膀胱癌发病风险的关系。然而，他们的结果仍然不一致，而且很少涉及吸烟或肿瘤状态在BC病例中与这种多态相关的确切作用。因此，这一元分析旨在揭示这种关联。方法：应用计算机检索PubMed、PMC、EMBASE、Web of Science等数据库，检索截至2018年5月30日的符合条件的研究。利用合并优势比(OR)和95%可信区间(CI)，在5种遗传比较模型下评估TP53密码子72多态与BC易感性的关系。结果：最终，这项荟萃分析纳入了22项适用研究，包括3,791个BC病例和4,917个对照。结果表明，等位基因模式OR=1.19，95%CI=1.04~1.34；显性模式OR=1.27，95%CI=1.06~1.52；纯合子模式OR=1.36，95%CI=1.03~1.80，与亚洲人群患乳腺癌的风险相关，而在高加索人群中呈阴性结果。在亚洲人群TP53密码子72多态与BC肿瘤分期的关系中，等位基因模型OR=1.68，95%CI=1.04~2.72；显性模型OR=2.46，95%CI=1.08~5.61；杂合子模型OR=2.32，95%CI=1.04~5.14；纯合子模型OR=2.66，95%CI=1.04~6.81。然而，未发现该基因多态性与BC肿瘤分级之间的关系。此外，TP53密码子72多态性与吸烟状况有显著相关性(等位基因模型OR=1.40，95%CI=1.06~1.84；显性模型OR=1.72，95%CI=1.18~2.50；杂合子模型OR=1.77，95%CI=1.19~2.64)。结论：本研究结果揭示了TP53密码子72多态与亚洲人BC易感性显著相关。此外，在BC患者中，该基因多态与肿瘤分期、吸烟状况也呈正相关。
Background: Various studies had explored the relationship between TP53 codon 72 polymorphisms and the risk of bladder cancer (BC). However, their results remained inconsistent and the definite role of smoking or tumor status associated with this polymorphism in BC cases was seldom involved. Hence, this meta-analysis was to disclose such associations. Methods: Systematical and comprehensive retrieval of online databases PubMed, PMC, EMBASE and Web of Science were conducted to obtain eligible studies, up to May 30th, 2018. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were utilized to assess the associations between TP53 codon 72 polymorphisms and BC susceptibilities under five genetic comparison models. Results: Ultimately, this meta-analysis enrolled 22 applicable studies with 3,791 BC cases and 4,917 controls. Our results suggested that the variant genotypes were associated with BC risk in Asian subgroup (allele model: OR=1.19, 95% CI=1.04-1.34; dominant model: OR=1.27, 95% CI=1.06-1.52; homozygote model: OR=1.36, 95% CI=1.03-1.80), while negative outcomes were presented in Caucasians. In the relationship between TP53 codon 72 polymorphisms and BC tumor stage in Asian group, positive results were presented in allele model: OR=1.68, 95% CI=1.04-2.72; dominant model: OR=2.46, 95% CI=1.08-5.61; heterozygous model: OR=2.32, 95% CI=1.04-5.14; homozygote model: OR=2.66, 95% CI=1.04-6.81. However, no evidence was revealed between this polymorphism and BC tumor grade. Besides, significant associations were displayed between TP53 codon 72 polymorphism and smoking status (allele model: OR=1.40, 95% CI=1.06-1.84; dominant model OR=1.72, 95% CI=1.18-2.50; heterozygous model: OR=1.77, 95% CI=1.19-2.64). Conclusion: Taken together, our results shed light on that TP53 codon 72 polymorphism was significantly associated with the susceptibility to BC in Asians. In addition, positive associations were also revealed between this polymorphism and tumor stage/smoking status in BC cases.
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影响因子：
50.3
作者：
Post SM;Quintás-Cardama A;Pant V;Iwakuma T;Hamir A;Jackson JG;Maccio DR;Bond GL;Johnson DG;Levine AJ;Lozano G
通讯作者：
Lozano G
影响因子：
4.2
作者：
Lin HY;Huang CH;Yu TJ;Wu WJ;Yang MC;Lung FW
通讯作者：
Lung FW
影响因子：
1.2
作者：
Avirmed, Shiirevnyamba;Wang, Bo-Shen;Lee, Yi-Jang
通讯作者：
Lee, Yi-Jang
影响因子：
--
作者：
Chen, WC;Tsai, FJ;Li, CW
通讯作者：
Li, CW
DOI：
10.1196/annals.1299.137
发表时间：
2003-01-01
期刊：
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
影响因子：
--
作者：
Mabrouk, I;Baccouche, S;Gargouri, A
通讯作者：
Gargouri, A