Hematogenous metastasis of ovarian cancer: rethinking mode of spread.

Hematogenous metastasis of ovarian cancer: rethinking mode of spread.
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DOI:
10.1016/j.ccr.2014.05.002
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发表时间:
2014-07-14
期刊:
影响因子:
50.3
通讯作者:
Sood AK
Sood AK
中科院分区:
医学1区
文献类型:
--
作者:
Pradeep S;Kim SW;Wu SY;Nishimura M;Chaluvally-Raghavan P;Miyake T;Pecot CV;Kim SJ;Choi HJ;Bischoff FZ;Mayer JA;Huang L;Nick AM;Hall CS;Rodriguez-Aguayo C;Zand B;Dalton HJ;Arumugam T;Lee HJ;Han HD;Cho MS;Rupaimoole R;Mangala LS;Sehgal V;Oh SC;Liu J;Lee JS;Coleman RL;Ram P;Lopez-Berestein G;Fidler IJ;Sood AK

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卵巢癌有明显的转移到网膜的倾向,但卵巢癌扩散的潜在机制还不清楚。在这里,我们使用了一个联体共生模型,证明卵巢癌的优先血行转移到网膜。我们的研究表明ErbB 3-neuregulin 1(NRG 1)轴是血行性网膜转移的主要途径。卵巢癌细胞中ErbB 3和网膜中NRG 1水平的升高允许肿瘤细胞在网膜中定位和生长。卵巢癌中ErbB 3的缺失损害网膜转移我们的研究结果强调血行转移是卵巢癌转移的一个重要方式。这些发现对设计旨在预防和治疗卵巢癌转移的替代策略具有意义。
Ovarian cancer has a clear predilection for metastasis to the omentum, but the underlying mechanisms involved in ovarian cancer spread are not well understood. Here, we used a parabiosis model that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum. Our studies revealed that the ErbB3-neuregulin1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer impaired omental metastasis. Our results highlight hematogenous metastasis as an important mode of ovarian cancer metastasis. These findings have implications for designing alternative strategies aimed at preventing and treating ovarian cancer metastasis.
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