Tumour angiogenesis regulation by the miR-200 family.
Tumour angiogenesis regulation by the miR-200 family.
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DOI：
10.1038/ncomms3427
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发表时间：
2013
影响因子：
16.6
通讯作者：
Sood, Anil K.
中科院分区：
文献类型：
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作者：
Pecot, Chad V.;Rupaimoole, Rajesha;Yang, Da;Akbani, Rehan;Ivan, Cristina;Lu, Chunhua;Wu, Sherry;Han, Hee-Dong;Shah, Maitri Y.;Rodriguez-Aguayo, Cristian;Bottsford-Miller, Justin;Liu, Yuexin;Kim, Sang Bae;Unruh, Anna;Gonzalez-Villasana, Vianey;Huang, Li;Zand, Behrouz;Moreno-Smith, Myrthala;Mangala, Lingegowda S.;Taylor, Morgan;Dalton, Heather J.;Sehgal, Vasudha;Wen, Yunfei;Kang, Yu;Baggerly, Keith A.;Lee, Ju-Seog;Ram, Prahlad T.;Ravoori, Murali K.;Kundra, Vikas;Zhang, Xinna;Ali-Fehmi, Rouba;Gonzalez-Angulo, Ana-Maria;Massion, Pierre P.;Calin, George A.;Lopez-Berestein, Gabriel;Zhang, Wei;Sood, Anil K.
众所周知，miR-200家族可以抑制上皮-间质转化，这表明它可能在治疗上抑制转移生物学。然而，关于miR-200在不同癌症类型中抑制或促进转移中的作用的相互矛盾的报道留下了未解之谜。在这里，我们证明了基于miR-200在阻断肿瘤血管生成中的作用的临床结果的差异。我们证明miR-200通过直接和间接的机制抑制血管生成，通过靶向肿瘤内皮细胞和癌细胞分泌的白细胞介素-8和CXCL1。通过几个实验模型，我们证明了miR-200通过抑制血管生成在卵巢癌、肺癌、肾癌和基底样乳腺癌中的治疗潜力。miR-200成员进入肿瘤内皮后，转移和血管生成明显减少，并诱导血管正常化。miR-200在癌症依赖性环境中阻断癌症血管生成的作用定义了其作为潜在治疗剂的效用。
The miR-200 family is well known to inhibit the epithelial–mesenchymal transition, suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports regarding the role of miR-200 in suppressing or promoting metastasis in different cancer types have left unanswered questions. Here we demonstrate a difference in clinical outcome based on miR-200's role in blocking tumour angiogenesis. We demonstrate that miR-200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1 secreted by the tumour endothelial and cancer cells. Using several experimental models, we demonstrate the therapeutic potential of miR-200 delivery in ovarian, lung, renal and basal-like breast cancers by inhibiting angiogenesis. Delivery of miR-200 members into the tumour endothelium resulted in marked reductions in metastasis and angiogenesis, and induced vascular normalization. The role of miR-200 in blocking cancer angiogenesis in a cancer-dependent context defines its utility as a potential therapeutic agent.
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影响因子：
64.5
作者：
Acharyya S;Oskarsson T;Vanharanta S;Malladi S;Kim J;Morris PG;Manova-Todorova K;Leversha M;Hogg N;Seshan VE;Norton L;Brogi E;Massagué J
通讯作者：
Massagué J
影响因子：
50.3
作者：
Cooke VG;LeBleu VS;Keskin D;Khan Z;O'Connell JT;Teng Y;Duncan MB;Xie L;Maeda G;Vong S;Sugimoto H;Rocha RM;Damascena A;Brentani RR;Kalluri R
通讯作者：
Kalluri R
影响因子：
4.8
作者：
Fasanaro, Pasquale;D'Alessandra, Yuri;Martelli, Fabio
通讯作者：
Martelli, Fabio
通过循环癌细胞自种肿瘤自种。
影响因子：
64.5
作者：
Kim MY;Oskarsson T;Acharyya S;Nguyen DX;Zhang XH;Norton L;Massagué J
通讯作者：
Massagué J
影响因子：
--
作者：
Cochrane DR;Howe EN;Spoelstra NS;Richer JK
通讯作者：
Richer JK