Infant body composition and adipokine concentrations in relation to maternal gestational weight gain.
Infant body composition and adipokine concentrations in relation to maternal gestational weight gain.
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DOI：
10.2337/dc13-2265
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发表时间：
2014-05
期刊：
影响因子：
16.2
通讯作者：
Franks PW
中科院分区：
文献类型：
--
作者：
Estampador AC;Pomeroy J;Renström F;Nelson SM;Mogren I;Persson M;Sattar N;Domellöf M;Franks PW
探讨母亲妊娠期体重增加与体组成的关系及其对4月龄子代体组成、脂肪细胞因子、葡萄糖和胰岛素浓度的影响。这是一项前瞻性研究，包括31对母婴（N = 62）。使用双标记水评估母体的身体成分。在4个月时使用空气置换容积描记仪评估婴儿身体组成，并测定静脉血中葡萄糖、胰岛素、脂联素、白细胞介素-6 （IL-6）和瘦素浓度。妊娠中期体重增加率与婴儿脂肪量显著相关（r = 0.41, P = 0.03）；妊娠后期妊娠体重率与婴儿无脂质量显著相关（r = 0.37, P = 0.04）。婴儿出生体重也与婴儿4个月时的无脂质量密切相关（r = 0.63, P = 0.0002）。母亲BMI和母亲脂肪量与婴儿IL-6浓度呈显著负相关（r = - 0.60, P = 0.002和r = - 0.52, P = 0.01）。婴儿无脂质量与婴儿脂联素浓度呈负相关（r = - 0.48, P = 0.008），与经胰岛素浓度调整后的婴儿血糖呈正相关（r = 0.42, P = 0.04）。未观察到瘦素的显著相关性。母亲体重增加的时间对4个月大婴儿的身体组成有不同的影响，这反过来又会影响婴儿的葡萄糖和脂肪因子浓度。
To investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months. This was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations. Rate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late pregnancy was significantly associated with infant fat-free mass (r = 0.37, P = 0.04). Infant birth weight was also strongly correlated with infant fat-free mass at 4 months (r = 0.63, P = 0.0002). Maternal BMI and maternal fat mass were strongly inversely associated with infant IL-6 concentrations (r = −0.60, P = 0.002 and r = −0.52, P = 0.01, respectively). Infant fat-free mass was inversely related to infant adiponectin concentrations (r = −0.48, P = 0.008) and positively correlated with infant blood glucose adjusted for insulin concentrations (r = 0.42, P = 0.04). No significant associations for leptin were observed. Timing of maternal weight gain differentially impacts body composition of the 4-month-old infant, which in turn appears to affect the infant’s glucose and adipokine concentrations.
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怀孕胰岛素，葡萄糖和BMI为非糖尿病母亲的出生结果做出了贡献。
影响因子：
16.2
作者：
Ong KK;Diderholm B;Salzano G;Wingate D;Hughes IA;MacDougall J;Acerini CL;Dunger DB
通讯作者：
Dunger DB
DOI：
10.3945/ajcn.2009.29128
发表时间：
2010-06
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Crozier SR;Inskip HM;Godfrey KM;Cooper C;Harvey NC;Cole ZA;Robinson SM;Southampton Women's Survey Study Group
通讯作者：
Southampton Women's Survey Study Group
影响因子：
2.5
作者：
POISSONNET, CM;BURDI, AR;BOOKSTEIN, FL
通讯作者：
BOOKSTEIN, FL
影响因子：
10.9
作者：
Christodoulides, Constantinos;Lagathu, Claire;Sethi, Jaswinder K.;Vidal-Puig, Antonio
通讯作者：
Vidal-Puig, Antonio
影响因子：
7.7
作者：
Franks, Paul W.;Hanson, Robert L.;Looker, Helen C.
通讯作者：
Looker, Helen C.