Nematode-Applied Technology for Human Tumor Microenvironment Research and Development.
Nematode-Applied Technology for Human Tumor Microenvironment Research and Development.
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DOI：
10.3390/cimb44020065
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发表时间：
2022-02-21
影响因子：
3.1
通讯作者：
Ishii H
中科院分区：
文献类型：
--
作者：
di Luccio E;Kaifuchi S;Kondo N;Chijimatsu R;Vecchione A;Hirotsu T;Ishii H
线虫，如秀丽隐杆线虫，对癌症的研究起到了重要作用。最近，它们作为强大的癌症生物诊断工具的重要性已经显现，而且还用于机制分析和药物发现。预计线虫应用技术将促进人类肿瘤微环境的研究和开发。自上个世纪以来，在癌症研究的历史上，线虫一直是发现癌症微环境的重要模式生物。首先，微小RNA（microRNAs，miRNAs）是一种非编码的小分子RNA，具有控制细胞分化的多种功能，它首先在C. elegans，并已积极纳入癌症研究，特别是在癌症基因组缺陷的研究。第二，线虫出色的嗅觉已被应用于疾病的诊断，特别是难治性肿瘤，如人类胰腺癌，通过感测来自异质性癌症微环境的复杂挥发性化合物，这些化合物难以使用普通分析方法进行分析。第三，线虫模型系统可以通过直接观察来帮助评估侵入体，即细胞侵入现象，这为癌症研究提供了一个新的方向，有助于阐明复杂的细胞间通讯。在这篇前沿综述中，我们强调了癌症研究历史上的里程碑，并从一个独特的角度关注线虫在癌症研究中对人类精准医学的贡献的最新信息。
Nematodes, such as Caenorhabditis elegans, have been instrumental to the study of cancer. Recently, their significance as powerful cancer biodiagnostic tools has emerged, but also for mechanism analysis and drug discovery. It is expected that nematode-applied technology will facilitate research and development on the human tumor microenvironment. In the history of cancer research, which has been spurred by numerous discoveries since the last century, nematodes have been important model organisms for the discovery of cancer microenvironment. First, microRNAs (miRNAs), which are noncoding small RNAs that exert various functions to control cell differentiation, were first discovered in C. elegans and have been actively incorporated into cancer research, especially in the study of cancer genome defects. Second, the excellent sense of smell of nematodes has been applied to the diagnosis of diseases, especially refractory tumors, such as human pancreatic cancer, by sensing complex volatile compounds derived from heterogeneous cancer microenvironment, which are difficult to analyze using ordinary analytical methods. Third, a nematode model system can help evaluate invadosomes, the phenomenon of cell invasion by direct observation, which has provided a new direction for cancer research by contributing to the elucidation of complex cell–cell communications. In this cutting-edge review, we highlight milestones in cancer research history and, from a unique viewpoint, focus on recent information on the contributions of nematodes in cancer research towards precision medicine in humans.
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影响因子：
3.7
作者：
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影响因子：
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影响因子：
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影响因子：
25
作者：
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通讯作者：
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