Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations.
Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations.
复制标题
当雾化赋形剂增强生长（EEG）表面活性剂粉末制剂时，低空气体积干粉吸入器（LV-DPI）的性能。
DOI：
10.1208/s12249-021-01998-9
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发表时间：
2021-04-15
影响因子：
3.3
通讯作者：
Hindle M
中科院分区：
文献类型：
--
作者：
Boc S;Momin MAM;Farkas DR;Longest W;Hindle M
有效输送以少量空气分散的干粉气溶胶具有挑战性。本研究旨在开发一种高效的干粉吸入器 (DPI)，能够以少量 (3 mL) 分散空气输送喷雾干燥的 Survanta-EEG 粉末 (3–10 mg)。对基础低风量驱动 DPI 进行了一系列迭代设计修改。修改包括用一体式剂量容纳室替换原始胶囊室、改变通过装置的夹带气流路径（从单侧（SS）到直通（ST））、改变进气孔数量（从1个到3个）、改变出口输送管长度（45、55和90毫米）和内径（0.60、0.89和1.17毫米）。通过确定修改和粉末填充质量对喷雾干燥 Survanta-EEG 粉末的气溶胶性能的影响来评估修改后的装置。还评估了最佳 DPI 雾化微粉的能力。优化的剂量控制单元 DPI 具有 0.21 mL 粉末室、ST 气流路径、三个 0.60 mm 进气孔和内径 0.89 mm 的 90 mm 出口输送管。最佳装置的粉末分散特性与填充质量无关，在一次 3 mL 驱动中具有良好的粉末排空性。在填充质量为 10 毫克时，该设备的发射质量为 5.3 毫克，气溶胶 Dv50 为 2.7 微米。 3 次 3 mL 驱动后，>85% 的喷雾干燥粉末从装置中排出。在一次 3 mL 驱动中，采用微粉化沙丁胺醇硫酸盐的最佳装置的发射质量> 10 mg 标称填充质量的 72%。经过设计优化，DPI 能够以 3 mL 的分散空气量实现高效性能，从而雾化 Survanta-EEG 粉末。
Efficient delivery of dry powder aerosols dispersed with low volumes of air is challenging. This study aims to develop an efficient dry powder inhaler (DPI) capable of delivering spray-dried Survanta-EEG powders (3–10 mg) with a low volume (3 mL) of dispersion air. A series of iterative design modifications were made to a base low air volume actuated DPI. The modifications included the replacement of the original capsule chamber with an integral dose containment chamber, alteration of the entrainment air flow path through the device (from single-sided (SS) to straight through (ST)), change in the number of air inlet holes (from one to three), varying the outlet delivery tube length (45, 55 and 90 mm) and internal diameter (0.60, 0.89 and 1.17 mm). The modified devices were evaluated by determining the influence of the modifications and powder fill mass on aerosol performance of spray-dried Survanta-EEG powders. The optimal DPI was also evaluated for its ability to aerosolize a micronized powder. The optimized dose containment unit DPI had a 0.21 mL powder chamber, ST airflow path, three-0.60 mm air inlet holes, and 90 mm outlet delivery tube with 0.89 mm internal diameter. The powder dispersion characteristics of the optimal device was independent of fill mass with good powder emptying in one 3 mL actuation. At 10 mg fill mass, this device had an emitted mass of 5.3 mg with an aerosol Dv50 of 2.7 µm. After three 3 mL actuations, >85% of the spray-dried powder was emitted from the device. The emitted mass of the optimal device with micronized albuterol sulfate was >72% of the nominal fill mass of 10 mg in one 3 mL actuation. Design optimization produced a DPI capable of efficient performance with a dispersion air volume of 3 mL to aerosolize Survanta-EEG powders.
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影响因子：
5.2
作者：
Laube, Beth L.;Sharpless, Gail;Powell, Kenneth
通讯作者：
Powell, Kenneth
DOI：
10.1089/jamp.2020.1593
发表时间：
2020-05-21
影响因子：
3.4
作者：
Gninzeko, Franck J. Kamga;Valentine, Michael S.;Heise, Rebecca L.
通讯作者：
Heise, Rebecca L.
影响因子：
1.7
作者：
Gupta S;Donn SM
通讯作者：
Donn SM
影响因子：
3.8
作者：
Jalalipour, Monireh;Najafabadi, Adolhossien Rouholamini;Tajerzadeh, Hosnieh
通讯作者：
Tajerzadeh, Hosnieh
DOI：
10.1128/aem.24.5.812-818.1972
发表时间：
1972-01-01
期刊：
APPLIED MICROBIOLOGY
影响因子：
--
作者：
FAIRCHILD, GA
通讯作者：
FAIRCHILD, GA