Sight restoration reverses blindness-induced cross-modal functional connectivity changes between the visual and somatosensory cortex at rest.
Sight restoration reverses blindness-induced cross-modal functional connectivity changes between the visual and somatosensory cortex at rest.
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DOI：
10.3389/fnins.2022.902866
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发表时间：
2022
影响因子：
4.3
通讯作者：
Weiland, James
中科院分区：
文献类型：
--
作者：
Nadvar, Negin;Stiles, Noelle;Choupan, Jeiran;Patel, Vivek;Ameri, Hossein;Shi, Yonggang;Liu, Zhongming;Jonides, John;Weiland, James
关键词：
静息状态功能连接（rsFC）已被用于评估视力丧失对大脑可塑性的影响。随着视力恢复疗法的出现，rsFC分析提供了一种评估视力恢复后功能变化的方法。我们的研究表明，与重度视网膜色素变性（RP）患者相比，Argus II视网膜假体患者中失明诱导的rsFC变化部分逆转。对于10名健康对照（HC）、10名RP和7名Argus II受试者，我们的研究包括每名受试者进行4次静息态功能磁共振成像（fMRI）。rsFC图以初级视皮层（V1）作为种子创建。RP > HC、Argus II > RP和Argus II > HC的rsFC组对比图显示，对于三种对比，中央后回（PostCG）中的区域相对于V1的rsFC分别显著减少、显著增强和无显著变化。这些结果也通过试验组之间的相应V1-PostCG ROI-ROI分析得到证实。最后，PostCG区域中V1的显著rsFC范围在HC中为5，961，在RP中为0，在Argus II组中为842 mm 3。我们的研究结果表明，视觉-体感rsFC减少失明后，与以前的研究结果一致。这种连通性增强视力恢复与Argus II，代表了逆转的变化，在休息期间表现出的跨模态功能可塑性，尽管由Argus II患者获得的初步视力。未来对这种罕见疾病的大量测试受试者的调查可以进一步揭示我们大脑在应对视力恢复时的重组能力。
Resting-state functional connectivity (rsFC) has been used to assess the effect of vision loss on brain plasticity. With the emergence of vision restoration therapies, rsFC analysis provides a means to assess the functional changes following sight restoration. Our study demonstrates a partial reversal of blindness-induced rsFC changes in Argus II retinal prosthesis patients compared to those with severe retinitis pigmentosa (RP). For 10 healthy control (HC), 10 RP, and 7 Argus II subjects, four runs of resting-state functional magnetic resonance imaging (fMRI) per subject were included in our study. rsFC maps were created with the primary visual cortex (V1) as the seed. The rsFC group contrast maps for RP > HC, Argus II > RP, and Argus II > HC revealed regions in the post-central gyrus (PostCG) with significant reduction, significant enhancement, and no significant changes in rsFC to V1 for the three contrasts, respectively. These findings were also confirmed by the respective V1-PostCG ROI-ROI analyses between test groups. Finally, the extent of significant rsFC to V1 in the PostCG region was 5,961 in HC, 0 in RP, and 842 mm3 in Argus II groups. Our results showed a reduction of visual-somatosensory rsFC following blindness, consistent with previous findings. This connectivity was enhanced following sight recovery with Argus II, representing a reversal of changes in cross-modal functional plasticity as manifested during rest, despite the rudimentary vision obtained by Argus II patients. Future investigation with a larger number of test subjects into this rare condition can further unveil the profound ability of our brain to reorganize in response to vision restoration.
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影响因子：
5.7
作者：
Iraji A;Calhoun VD;Wiseman NM;Davoodi-Bojd E;Avanaki MRN;Haacke EM;Kou Z
通讯作者：
Kou Z
影响因子：
13.7
作者：
Ashtari M;Nikonova ES;Marshall KA;Young GJ;Aravand P;Pan W;Ying GS;Willett AE;Mahmoudian M;Maguire AM;Bennett J
通讯作者：
Bennett J
影响因子：
8.1
作者：
Dorn, Jessy D.;Ahuja, Ashish K.;Caspi, Avi;da Cruz, Lyndon;Dagnelie, Gislin;Sahel, Jose-Alain;Greenberg, Robert J.;McMahon, Matthew J.
通讯作者：
McMahon, Matthew J.
影响因子：
3
作者：
Cunningham, Samantha I.;Shi, Yonggang;Tjan, Bosco S.
通讯作者：
Tjan, Bosco S.
静息态功能 MRI：原发性开角型青光眼患者视觉皮层的功能连接分析
影响因子：
4.8
作者：
Dai, Hui;Morelli, John N.;Li, Yonggang
通讯作者：
Li, Yonggang