The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis.
The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis.
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DOI：
10.1001/2013.jamaophthalmol.221
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发表时间：
2013-02
影响因子：
8.1
通讯作者：
McMahon, Matthew J.
中科院分区：
文献类型：
--
作者：
Dorn, Jessy D.;Ahuja, Ashish K.;Caspi, Avi;da Cruz, Lyndon;Dagnelie, Gislin;Sahel, Jose-Alain;Greenberg, Robert J.;McMahon, Matthew J.
研究植入60电极Argus II（Second Sight Medical Products Inc）视网膜假体系统的28名盲人受试者检测移动物体方向的能力。作为全球多个临床研究中心1/2期可行性研究的一部分，患有色素性视网膜炎的失明受试者（双眼裸眼光感或更差）植入了Argus II假体。该实验测量了他们在3种条件下检测平板显示器上高对比度移动杆的运动方向的能力：假肢系统打开和空间信息的1对1映射，系统关闭，以及系统打开但随机混乱的空间信息。15名受试者（54%）能够使用假体系统执行任务的效果显著优于使用剩余视力的情况，2名受试者的剩余视力表现显著更好，11名受试者的表现无差异。在15名表现较好的受试者中，有11名可用于后续测试，其中10名受试者在正常空间信息下的表现明显优于在杂乱空间信息下的表现。这项工作表明，植入Argus II视网膜假体的盲人受试者能够执行他们无法用原生视觉完成的运动检测任务，证实视网膜的电刺激通过同步激活多个电极提供空间信息。
To investigate the ability of 28 blind subjects implanted with a 60-electrode Argus II (Second Sight Medical Products Inc) retinal prosthesis system to detect the direction of a moving object. Blind subjects (bare light perception or worse in both eyes) with retinitis pigmentosa were implanted with the Argus II prosthesis as part of a phase 1/2 feasibility study at multiple clinical sites worldwide. The experiment measured their ability to detect the direction of motion of a high-contrast moving bar on a flatscreen monitor in 3 conditions: with the prosthesis system on and a 1-to-1 mapping of spatial information, with the system off, and with the system on but with randomly scrambled spatial information. Fifteen subjects (54%) were able to perform the task significantly better with their prosthesis system than they were with their residual vision, 2 subjects had significantly better performance with their residual vision, and no difference was found for 11 subjects. Of the 15 better-performing subjects, 11 were available for follow-up testing, and 10 of them had significantly better performance with normal rather than with scrambled spatial information. This work demonstrates that blind subjects implanted with the Argus II retinal prosthesis were able to perform a motion detection task they could not do with their native vision, confirming that electrical stimulation of the retina provides spatial information from synchronized activation of multiple electrodes.
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DOI：
10.1098/rspb.2010.1747
发表时间：
2011-05-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Zrenner E;Bartz-Schmidt KU;Benav H;Besch D;Bruckmann A;Gabel VP;Gekeler F;Greppmaier U;Harscher A;Kibbel S;Koch J;Kusnyerik A;Peters T;Stingl K;Sachs H;Stett A;Szurman P;Wilhelm B;Wilke R
通讯作者：
Wilke R
影响因子：
--
作者：
STONE, JL;BARLOW, WE;MILAM, AH
通讯作者：
MILAM, AH
影响因子：
1.8
作者：
Zrenner, E;Stett, A;Haemmerle, H
通讯作者：
Haemmerle, H
影响因子：
4.1
作者：
Besch, D.;Sachs, H.;Gekeler, F.
通讯作者：
Gekeler, F.
影响因子：
4.4
作者：
Roessler, Gernot;Laube, Thomas;Walter, Peter
通讯作者：
Walter, Peter