Distribution and functional relevance of connexins in renin-producing cells

Distribution and functional relevance of connexins in renin-producing cells
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肾素产生细胞中连接蛋白的分布和功能相关性

DOI:
10.1007/s00424-012-1134-7
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发表时间:
2013
期刊:
Pflügers Archiv - European Journal of Physiology
影响因子:
--
通讯作者:
Kurtz A
Kurtz A
中科院分区:
--
文献类型:
--
作者:
Wagner C;Kurtz A

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肾小球细胞水平的肾素合成和分泌受神经递质、激素、旁分泌和机械信号的调节。尽管形态学证据表明,组成肾小球区的细胞之间通过连接蛋白进行的肾素细胞间的强烈通讯,但长期以来,肾素分泌细胞的功能行为一直被认为是单个分离细胞的功能行为。近年来的研究结果首次阐明了连接蛋白在控制肾素分泌和定位肾脏中的肾素分泌细胞方面的功能相关性。这篇简短的评论旨在总结这些发现,并试图将它们置于功能背景下。
Renin synthesis and renin secretion at the level of renal juxtaglomerular cells are regulated by neurotransmitters, hormones, paracrine, and mechanical signals. Although morphological evidence has indicated an intense intercellular communication of renin cells via connexins between the cells composing the juxtaglomerlar area, the functional behavior of renin-secreting cells has been considered of that of individual isolated cells for a long time. Findings obtained during recent years shed first light on the functional relevance of connexins for the control of renin secretion and also for the positioning of renin-secreting cells in the kidney. This short review aims to summarize these findings and tries to set them into a functional context.
DOI: 10.1111/j.1476-5381.1974.tb09599.x
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