A comparison of the life goals program and treatment as usual for individuals with bipolar disorder.
A comparison of the life goals program and treatment as usual for individuals with bipolar disorder.
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DOI：
10.1176/ps.2009.60.9.1182
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Calabrese JR
中科院分区：
文献类型：
--
作者：
Sajatovic M;Davies MA;Ganocy SJ;Bauer MS;Cassidy KA;Hays RW;Safavi R;Blow FC;Calabrese JR
这项随机对照研究对社区精神卫生中心的 164 名双相情感障碍门诊患者进行了研究，这些患者接受了标准化心理教育（生活目标计划 [LGP]）或照常治疗，旨在确定各组之间在药物依从性态度和行为方面是否存在差异。患者被随机分配接受常规治疗 (N=80) 或常规治疗加 LGP (N=84)，并在基线以及 3、6 和 12 个月的随访时进行评估。主要结局是药物态度量表（DAI）和自我报告的治疗依从行为（SRTAB）评分相对于基线的变化。基线时，两组之间没有显着差异。略低于一半（N=41，49%）的 LGP 群体参加了大部分或全部（四到六次）LGP 会议，14%（N=12）参加了 1 到 3 个会议，37%（N=31）没有参加任何会议。在 12 个月的随访中，所有患者的 DAI 评分、SRTAB、症状、精神病理学和功能状态均有所改善，但两组之间没有显着差异。基线时抑郁严重程度越高，随着时间的推移，对治疗的态度越消极，但这一发现并不显着 (p=.056)。对LGP组人员的二次分析发现，与那些没有参加任何LGP会议的人相比，部分或全部参加LGP会议的人在3个月和6个月的随访中对药物的态度有所改善，但在12个月的随访中，三个LGP亚组之间没有发现差异。 12个月的随访中两组的治疗态度没有差异。低出勤率减轻了对主要结果的影响。如果不进行持续干预，LGP 的效果可能会随着时间的推移而消失，抑郁症患者对 LGP 的反应可能会降低。
This randomized controlled study of 164 outpatients with bipolar disorder in a community mental health center who received standardized psychoeducation (Life Goals Program [LGP]) or treatment as usual sought to determine whether there were differences between the groups in medication adherence attitudes and behaviors. Patients were randomly assigned to treatment as usual (N=80) or treatment as usual plus LGP (N=84) and were assessed at baseline and at the three-, six-, and 12-month follow-up. Primary outcomes were change in score from baseline on the Drug Attitude Inventory (DAI) and on self-reported treatment adherence behaviors (SRTAB). At baseline, there were no significant differences between the two groups. Slightly less than half (N=41, 49%) of the LGP group participated in most or all (four to six) LGP sessions, 14% (N=12) participated in one to three sessions, and 37% (N=31) did not participate in any sessions. At the 12-month follow-up there was improvement among all patients, with no significant differences between the two groups, in DAI scores, SRTAB, symptoms, psychopathology, and functional status. Greater depressive severity at baseline was associated with more negative attitudes toward treatment over time, although this finding was not significant (p=.056). Secondary analysis of persons in the LGP group found that compared with those who did not go to any LGP sessions, those with partial or full participation in LGP sessions had improved attitudes toward medication at the three- and six-month follow-up, but no difference was found between the three LGP subgroups by the 12-month follow-up. There were no differences between two groups in treatment attitudes at the 12-month follow-up. Low attendance rates mitigated effects on primary outcomes. Effects of LGP may become lost over time without ongoing intervention, and individuals with depression may have reduced response to LGP.
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影响因子：
3.8
作者：
Sajatovic, Martha;Biswas, Kousick;Bauer, Mark S.
通讯作者：
Bauer, Mark S.
影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC
影响因子：
5.4
作者：
Scott, J;Tacchi, MJ
通讯作者：
Tacchi, MJ
DOI：
10.3109/00048679209072068
发表时间：
1992-09-01
影响因子：
4.6
作者：
LEE, S;WING, YK;WONG, KC
通讯作者：
WONG, KC
影响因子：
5.9
作者：
COCHRAN, SD
通讯作者：
COCHRAN, SD