14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis.
14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis.
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DOI：
10.3389/fnmol.2017.00318
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发表时间：
2017
影响因子：
4.8
通讯作者：
Toyo-Oka K
中科院分区：
文献类型：
--
作者：
Cornell B;Toyo-Oka K
14-3-3蛋白是一个高度保守的多功能蛋白家族，在发育过程中在大脑中高度表达。累积起来，七种14-3-3同种型约占总可溶性脑蛋白的1%。在过去的十年中，已经积累了证据表明14-3-3蛋白家族在神经系统发育，特别是皮质发育中的重要性，并且最近被认为是许多神经发育过程中的关键调节剂。在这篇综述中，我们将讨论每个14-3-3亚型在大脑皮层发育中的已知作用，它们与人类神经发育障碍的关系，以及有待回答的挑战和问题。特别是，我们专注于14-3-3异构体和他们参与皮质发育的三个关键阶段：神经发生和分化，神经元迁移和神经形态发生和突触。
The 14-3-3 proteins are a family of highly conserved, multifunctional proteins that are highly expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make up approximately 1% of total soluble brain protein. Over the last decade, evidence has accumulated implicating the importance of the 14-3-3 protein family in the development of the nervous system, in particular cortical development, and have more recently been recognized as key regulators in a number of neurodevelopmental processes. In this review we will discuss the known roles of each 14-3-3 isoform in the development of the cortex, their relation to human neurodevelopmental disorders, as well as the challenges and questions that are left to be answered. In particular, we focus on the 14-3-3 isoforms and their involvement in the three key stages of cortical development; neurogenesis and differentiation, neuronal migration and neuromorphogenesis and synaptogenesis.
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影响因子：
2.9
作者：
Campbell, JK;Gurung, R;Mitchell, CA
通讯作者：
Mitchell, CA
影响因子：
2.5
作者：
Cornell, Brett;Wachi, Tomoka;Toyo-oka, Kazuhito
通讯作者：
Toyo-oka, Kazuhito
DOI：
10.1073/pnas.101122598
发表时间：
2001-05-22
影响因子：
11.1
作者：
Cahana, A;Escamez, T;Reiner, O
通讯作者：
Reiner, O
影响因子：
1.8
作者：
Cornell B;Toyo-oka K
通讯作者：
Toyo-oka K
影响因子：
6.9
作者：
Comparot, S;Lingiah, G;Martin, T
通讯作者：
Martin, T