Decreased interhemispheric coordination in schizophrenia: a resting state fMRI study.
Decreased interhemispheric coordination in schizophrenia: a resting state fMRI study.
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精神分裂症患者半球间协调能力下降：静息态功能磁共振成像研究
DOI：
10.1016/j.schres.2012.07.027
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发表时间：
2012-10
影响因子：
4.5
通讯作者：
Javitt DC
中科院分区：
文献类型：
--
作者：
Hoptman MJ;Zuo XN;D'Angelo D;Mauro CJ;Butler PD;Milham MP;Javitt DC
精神分裂症已越来越多地被概念化为一种大脑连接障碍，这在很大程度上是由于白色物质和功能连接（FC）研究的结果。这项工作主要集中在半球内的连接，但一些证据表明，胼胝体结构和半球间的相互作用异常。在这里，我们使用一种称为体素镜像同伦连接（VMHC）的技术来检查大脑中同伦点之间的功能连接。我们对23名健康对照者和25名精神分裂症或情感障碍患者的静息状态fMRI数据进行了VMHC分析。我们发现患者的VMHC在许多区域，特别是枕叶，丘脑和小脑中显著降低。在患者中未检测到VMHC增加的区域。中央后回延伸至中央前回的VMHC与PANSS总分相关。这些结果表明，精神分裂症患者的大脑半球间协调功能有实质性损害。
Schizophrenia has been increasingly conceptualized as a disorder of brain connectivity, in large part due to findings emerging from white matter and functional connectivity (FC) studies. This work has focused primarily on within-hemispheric connectivity, however some evidence has suggested abnormalities in callosal structure and interhemispheric interaction. Here we examined functional connectivity between homotopic points in the brain using a technique called voxel-mirrored homotopic connectivity (VMHC). We performed VMHC analyses on resting state fMRI data from 23 healthy controls and 25 patients with schizophrenia or schizoaffective disorder. We found highly significant reductions in VMHC in patients for a number of regions, particularly the occipital lobe, the thalamus, and the cerebellum. No regions of increased VMHC were detected in patients. VMHC in the postcentral gyrus extending into the precentral gyrus was correlated with PANSS Total scores. These results show substantial impairment of interhemispheric coordination in schizophrenia.
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影响因子：
10.6
作者：
Butler PD;Silverstein SM;Dakin SC
通讯作者：
Dakin SC
影响因子：
1.7
作者：
Foxe, JJ;Doniger, GM;Javitt, DC
通讯作者：
Javitt, DC
影响因子：
6.9
作者：
Cheung, V.;Cheung, C.;Chua, S. E.
通讯作者：
Chua, S. E.
影响因子：
3.6
作者：
DIMOND, SJ
通讯作者：
DIMOND, SJ
影响因子：
2.6
作者：
BOWERS, D;HEILMAN, KM
通讯作者：
HEILMAN, KM