MATLAB toolbox for functional connectivity.

MATLAB toolbox for functional connectivity.
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DOI:
10.1016/j.neuroimage.2009.05.089
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发表时间:
2009-10-01
期刊:
影响因子:
5.7
通讯作者:
Siegle, Greg
Siegle, Greg
中科院分区:
医学1区
文献类型:
--
作者:
Zhou, Dongli;Thompson, Wesley K.;Siegle, Greg

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术语"功能连接性"用于表示在休息状态下或在处理外部刺激时空间上不同的脑区域之间的激活的相关性。功能性连接已经被广泛评价了几种功能性神经影像学方法,特别是PET和fMRI。然而,这些关系已被量化使用非常不同的措施和程度,他们指数相同的结构是不清楚的。我们在一个新的免费MATLAB工具箱中实现了各种功能连接措施。这些措施分为两组:整个时间序列和审判为基础的方法。我们评估这些措施,通过模拟不同模式的功能连接,并提供建议,为他们的使用。我们还将这些措施应用到以前发表的功能磁共振成像数据集,其中背侧前扣带皮层(dACC)和背外侧前额叶皮层(DLPFC)的活动进行了评估,在32个对照组的数字排序任务。虽然所有实施的措施表明,在事件相关的任务dACC和DLPFC活动之间的功能连接,不同的参与者似乎表现出质的不同的关系。
The term “functional connectivity” is used to denote correlations in activation among spatially-distinct brain regions, either in a resting state or when processing external stimuli. Functional connectivity has been extensively evaluated with several functional neuroimaging methods, particularly PET and fMRI. Yet these relationships have been quantified using very different measures and the extent to which they index the same constructs is unclear. We have implemented a variety of these functional connectivity measures in a new freely-available MATLAB toolbox. These measures are categorized into two groups: whole time-series and trial-based approaches. We evaluate these measures via simulations with different patterns of functional connectivity and provide recommendations for their use. We also apply these measures to a previously published fMRI data set in which activity in dorsal anterior cingulate cortex (dACC) and dorsolateral prefrontal cortex (DLPFC) was evaluated in 32 control subjects during a digit sorting task. Though all implemented measures demonstrate functional connectivity between dACC and DLPFC activity during event-related tasks, different participants appeared to display qualitatively different relationships.
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