Cumulative childhood adversity and adult cardiometabolic disease: A meta-analysis.
Cumulative childhood adversity and adult cardiometabolic disease: A meta-analysis.
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DOI：
10.1037/hea0000637
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Matthews KA
中科院分区：
文献类型：
--
作者：
Jakubowski KP;Cundiff JM;Matthews KA
不良的童年经历可能与成年后的心脏代谢发病率和死亡率有关。关于累积逆境指数、样本量、人口统计学和协变量中的项目类型，本文献存在异质性。本综述使用定量荟萃分析来研究这种关联和潜在的调节剂。纳入的研究测量了累积逆境（0至18岁期间至少2次不良童年经历的指数）和心血管代谢疾病：18岁或以上的心血管（CVD）临床结局（高血压、冠心病、缺血性心脏病、心肌梗死、中风、脑血管疾病）和代谢结局（糖尿病、代谢综合征）。考虑到对比值比（OR）与风险比（HR）的不同解释，单独汇总效应。总体而言，纳入了基于179，612名受试者的9项HR研究（15项效应）和基于247，393名受试者的29项OR研究（62项效应）。主要基于回顾性评估的逆境，联合研究显示累积的童年逆境对成人心脏代谢疾病的显著估计影响（HR=1.42，95% CI [1.20，1.67]; OR=1.36 [1.27，1.46]）。结果因心脏代谢疾病的类型、分析策略以及协变量的数量和类型而有所不同。文献表明，累积的童年逆境与成人心脏代谢疾病适度相关，对CVD临床结局的影响更强。由于缺乏对逆境的一致的操作和概念定义，以及缺乏前瞻性的设计，这些结论受到了影响。现在是进一步评估对成人心脏代谢疾病有最大影响的儿童期事件的类型和时间的时候了。
Adverse childhood experiences may be associated with cardiometabolic morbidity and mortality in adulthood. There is heterogeneity in this literature regarding the type of items in cumulative adversity indices, sample sizes and demographics, and covariates. The present review used quantitative meta-analysis to examine this association and potential moderators. Included studies had a measure of cumulative adversity (an index of at least 2 adverse childhood experiences from age 0 to 18) and a measure of cardiometabolic disease: cardiovascular (CVD) clinical outcomes (hypertension, coronary heart disease, ischemic heart disease, myocardial infarction, stroke, cerebrovascular disease) and metabolic outcomes (diabetes, metabolic syndrome) at age 18 or older. Given different interpretations of odds ratios (OR) versus hazard ratios (HR), effects were pooled separately. Overall, 9 HR studies (15 effects) based on 179,612 participants and 29 OR studies (62 effects) based on 247,393 participants were included. Based largely on retrospectively-assessed adversity, combined studies showed a significant estimated effect of cumulative childhood adversity on adult cardiometabolic disease (HR=1.42, 95% CI [1.20, 1.67]; OR=1.36 [1.27, 1.46]). Results varied somewhat by type of cardiometabolic disease, analytic strategy, and number and type of covariates. The literature suggests that cumulative childhood adversity is modestly related to adult cardiometabolic disease, with effects somewhat stronger for CVD clinical outcomes. The absence of a consistent operational and conceptual definition of adversity and paucity of prospective designs temper the conclusions. It is time for further evaluation of the types and timing of childhood events that have maximal impact on adult cardiometabolic disease.
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影响因子：
4.8
作者：
Almuneef, Maha;ElChoueiry, Nathalie;Al-Eissa, Majid
通讯作者：
Al-Eissa, Majid
DOI：
10.1111/j.1749-6632.2009.05334.x
发表时间：
2010-01-01
期刊：
BIOLOGY OF DISADVANTAGE: SOCIOECONOMIC STATUS AND HEALTH
影响因子：
--
作者：
Cohen, Sheldon;Janicki-Deverts, Denise;Matthews, Karen A.
通讯作者：
Matthews, Karen A.
影响因子：
8
作者：
Brotman, Laurie Miller;Dawson-McClure, Spring;Ogedegbe, Gbenga
通讯作者：
Ogedegbe, Gbenga
影响因子：
4.8
作者：
Almuneef, Maha;Qayad, Mohammed;Albuhairan, Fadia
通讯作者：
Albuhairan, Fadia
影响因子：
--
作者：
Danese, Andrea;Moffitt, Terrie E.;Harrington, HonaLee;Milne, Barry J.;Polanczyk, Guilherme;Pariante, Carmine M.;Poulton, Richie;Caspi, Avshalom
通讯作者：
Caspi, Avshalom