Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.
Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.
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DOI：
10.1111/j.1532-5415.2009.02680.x
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发表时间：
2010-02
影响因子：
6.3
通讯作者：
Langa KM
中科院分区：
文献类型：
--
作者：
Okura T;Plassman BL;Steffens DC;Llewellyn DJ;Potter GG;Langa KM
评估神经精神症状的患病率，并检查其与功能限制的关系。横截面分析。老龄化，人口统计学和记忆研究（亚当斯）。71岁及以上的成年人样本（N = 856）来自健康与退休研究（HRS），这是一项具有全国代表性的51岁及以上美国成年人队列。使用神经精神量表确定是否存在神经精神症状（妄想、幻觉、激越、抑郁、冷漠、焦虑、去抑制、刺激和异常运动行为）。亚当斯中的共识小组分配了一个认知类别（正常认知;认知障碍，无痴呆（CIND）;轻度、中度或重度痴呆）。从HRS和亚当斯中获得功能限制、慢性疾病和社会人口统计学信息。43%的CIND患者和58%的痴呆患者表现出至少一种神经精神症状。抑郁是认知正常（12%）、CIND（30%）和轻度痴呆（25%）患者中最常见的个体症状，而冷漠（42%）和激越（41%）在重度痴呆患者中最常见。具有三种或三种以上症状和一种或多种临床显著症状的个体具有明显更高的功能限制几率。临床显著抑郁症患者的日常生活活动受限几率较高，临床显著抑郁症、焦虑或异常运动行为患者的工具性日常生活活动受限几率显著较高。神经精神症状在患有CIND和痴呆的老年人中非常普遍。在认知障碍患者中，更多的神经精神症状和一些特定的个体症状与功能限制密切相关。
To estimate the prevalence of neuropsychiatric symptoms and examine their association with functional limitations. Cross-sectional analysis. The Aging, Demographics, and Memory Study (ADAMS). A sample of adults aged 71 and older (N = 856) drawn from Health and Retirement Study (HRS), a nationally representative cohort of U.S. adults aged 51 and older. The presence of neuropsychiatric symptoms (delusions, hallucinations, agitation, depression, apathy, elation, anxiety, disinhibition, irritation, and aberrant motor behaviors) was identified using the Neuropsychiatric Inventory. A consensus panel in the ADAMS assigned a cognitive category (normal cognition; cognitive impairment, no dementia (CIND); mild, moderate, or severe dementia). Functional limitations, chronic medical conditions, and sociodemographic information were obtained from the HRS and ADAMS. Forty-three percent of individuals with CIND and 58% of those with dementia exhibited at least one neuropsychiatric symptom. Depression was the most common individual symptom in those with normal cognition (12%), CIND (30%), and mild dementia (25%), whereas apathy (42%) and agitation (41%) were most common in those with severe dementia. Individuals with three or more symptoms and one or more clinically significant symptoms had significantly higher odds of having functional limitations. Those with clinically significant depression had higher odds of activity of daily living limitations, and those with clinically significant depression, anxiety, or aberrant motor behaviors had significantly higher odds of instrumental activity of daily living limitations. Neuropsychiatric symptoms are highly prevalent in older adults with CIND and dementia. Of those with cognitive impairment, a greater number of total neuropsychiatric symptoms and some specific individual symptoms are strongly associated with functional limitations.
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影响因子：
5.7
作者：
Langa, KM;Plassman, BL;Willis, RJ
通讯作者：
Willis, RJ
影响因子：
2.1
作者：
Hwang, TJ;Masterman, DL;Cummings, JL
通讯作者：
Cummings, JL
DOI：
10.1111/j.1532-5415.1998.tb01075.x
发表时间：
1998-05-01
影响因子：
6.3
作者：
Grigsby, J;Kaye, K;Hamman, RF
通讯作者：
Hamman, RF
DOI：
10.1093/geronb/54b.5.s262
发表时间：
1999-09-01
影响因子：
6.2
作者：
Carlson, MC;Fried, LP;Brandt, J
通讯作者：
Brandt, J
影响因子：
4
作者：
Herrmann, Nathan;Lanctot, Krista L.;Nguyen, Elizabeth
通讯作者：
Nguyen, Elizabeth