Wavelengths for port wine stain laser treatment: influence of vessel radius and skin anatomy.
Wavelengths for port wine stain laser treatment: influence of vessel radius and skin anatomy.
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葡萄酒色斑激光治疗的波长：血管半径和皮肤解剖结构的影响。
DOI：
10.1088/0031-9155/42/1/002
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发表时间：
1997
影响因子：
3.5
通讯作者：
Nelson,JS
中科院分区：
文献类型：
--
作者：
vanGemert,MJ;Smithies,DJ;Verkruysse,W;Milner,TE;Nelson,JS
最近的Monte Carlo计算在现实的葡萄酒色斑（PWS）模型，包含许多均匀分布的血管表明在577和585 nm波长的血管损伤的深度相等。这一发现与临床经验和先前的理论相矛盾。从皮肤模型包含正常和PWS血管在不同的真皮层，我们估计分析的平均体积产热在最深的目标PWS血管。注量率分布近似比尔定律，这取决于组织的有效衰减系数，并包括一个均匀的分数体积血液浓度校正有限尺寸的血管。该模型预测585-587 nm波长在包含至少一层小半径血管的成人PWS中是最佳的。在浅表PWS中，通常在具有小半径血管的幼儿中，577-580 nm波长是最佳的。波长无关的结果类似于那些从蒙特卡罗模型是有效的，在单层PWS的大半径的船只。总之，最深靶向PWS血管中的体积产热可以在个体患者的基础上最大化。然而，585-587 nm波长的吸收在浅表病变中足够高，因此我们假设这些波长可被认为足以治疗任何PWS。
Recent Monte Carlo computations in realistic port wine stain (PWS) models containing numerous uniformly distributed vessels suggest equal depth of vascular injury at wavelengths of 577 and 585 nm. This finding contradicts clinical experience and previous theory. From a skin model containing normal and PWS vessels in separate dermal layers, we estimate analytically the average volumetric heat production in the deepest targeted PWS vessel. The fluence rate distribution is approximated by Beer's law, which depends upon the tissue's effective attenuation coefficient, and includes a homogeneous fractional volumetric blood concentration corrected for finite-size blood vessels. The model predicts 585-587 nm wavelengths are optimal in adult PWSs containing at least one layer of small-radius blood vessels. In superficial PWSs, typically in young children with small-radius vessels, 577-580 nm wavelengths are optimal. Wavelength-independent results similar to those from Monte Carlo models are valid in single-layered PWSs of large-radius vessels. In conclusion, the volumetric heat production in the deepest targeted PWS blood vessel can be maximized on an individual patient basis. However, absorption of 585-587 nm wavelengths is sufficiently high in superficial lesions, so we hypothesize that these wavelengths may be considered adequate for the treatment of any PWS.
使用闪光灯脉冲可调谐染料激光器治疗患有葡萄酒色斑的儿童。
DOI：
10.1056/nejm198902163200702
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tan,OT;Sherwood,K;Gilchrest,BA
通讯作者：
Gilchrest,BA
使用脉冲照射的血管特异性损伤的作用谱。
DOI：
10.1111/1523-1747.ep12696885
发表时间：
1989
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Tan,OT;Murray,S;Kurban,AK
通讯作者：
Kurban,AK