Radial construction of an arterial wall.
Radial construction of an arterial wall.
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DOI：
10.1016/j.devcel.2012.07.009
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发表时间：
2012-09-11
影响因子：
11.8
通讯作者：
Krasnow, Mark A.
中科院分区：
文献类型：
--
作者：
Greif, Daniel M.;Kumar, Maya;Lighthouse, Janet K.;Hum, Justine;An, Andrew;Ding, Ling;Red-Horse, Kristy;Espinoza, F. Heman;Olson, Lorin;Offermanns, Stefan;Krasnow, Mark A.
一些最严重的疾病涉及动脉壁的大小和结构改变。阐明动脉壁是如何构建的可以帮助理解这些疾病，但是关于肌细胞和外膜层的同心层如何在内皮管周围组装和形成图案的知之甚少。利用组织化学、克隆和遗传分析，我们发现肺动脉壁是由内向外放射状地由两个独立但协调的过程构成的。一种是从周围间充质连续诱导连续的细胞层。另一种是内层细胞通过发育调节的细胞重定向和径向迁移控制外层的侵入。我们提出，径向信号梯度控制这些过程，并提供证据，PDGF-B和至少一个其他信号作出贡献。这种径向信号通路的调节可能是血管特异性差异和动脉壁大小和结构病理变化的基础。
Some of the most serious diseases involve altered size and structure of the arterial wall. Elucidating how arterial walls are built could aid understanding of these diseases, but little is known about how concentric layers of muscle cells and the outer adventitial layer are assembled and patterned around endothelial tubes. Using histochemical, clonal, and genetic analysis in mice, here we show that the pulmonary artery wall is constructed radially, from the inside out, by two separate but coordinated processes. One is sequential induction of successive cell layers from surrounding mesenchyme. The other is controlled invasion of outer layers by inner layer cells through developmentally-regulated cell reorientation and radial migration. We propose that a radial signal gradient controls these processes and provide evidence that PDGF-B and at least one other signal contribute. Modulation of such radial signaling pathways may underlie vessel-specific differences and pathological changes in arterial wall size and structure.
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