Nonhomogeneous volume conduction effects affecting needle electromyography: an analytical and simulation study.
Nonhomogeneous volume conduction effects affecting needle electromyography: an analytical and simulation study.
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DOI：
10.1088/1361-6579/ac38c0
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发表时间：
2021-12-28
影响因子：
3.2
通讯作者：
Sanchez B
中科院分区：
文献类型：
--
作者：
Luo X;Wang S;Rutkove SB;Sanchez B
针式肌电图（EMG）用于研究神经肌肉疾病患者肌纤维特性的电行为。然而，由于电位空间传播的复杂性，在非均匀的患病肌肉，体积传导效应的全面理解仍然是难以捉摸的。在这里，我们开发了一个框架来研究细胞外异常和电极定位对细胞外局部场电位（LFP）记录的传导效应。该框架描述了在各向同性、非均匀（即，两个组织）模型。数值和有限元模型模拟研究的传导效应，在原型单极肌电图测量。记录的LFP在幅度、相位和持续时间方面受到电极位置的影响，电极位置与具有不同电特性的组织附近有关。该框架揭示了影响LFP的多种机制的影响，包括源电极和组织电特性之间的距离的变化。我们的建模预测可能会导致新的方法来解释体积传导对记录的EMG活动的影响，例如在神经肌肉疾病，导致肌肉组织的结构和成分的变化。这些变化将通过改变导体介质的电特性来表现自己，并将影响受影响组织区域中的记录电位。
Needle electromyography (EMG) is used to study the electrical behavior of myofiber properties in patients with neuromuscular disorders. However, due to the complexity of electrical potential spatial propagation in nonhomogeneous diseased muscle, a comprehensive understanding of volume conduction effects remains elusive. Here, we develop a framework to study the conduction effect of extracellular abnormalities and electrode positioning on extracellular local field potential (LFP) recordings. The framework describes the macroscopic conduction of electrical potential in an isotropic, nonhomogeneous (i.e., two tissue) model. Numerical and finite element model simulations are provided to study the conduction effect in prototypical monopolar EMG measurements. LFPs recorded are influenced in amplitude, phase and duration by the electrode position in regards to the vicinity of tissue with different electrical properties. The framework reveals the influence of multiple mechanisms affecting LFPs including changes in the distance between the source – electrode and tissue electrical properties. Our modeled predictions may lead to new ways for interpreting volume conduction effects on recorded EMG activity, for example in neuromuscular diseases that cause structural and compositional changes in muscle tissue. These change will manifest itself by changing the electric properties of the conductor media and will impact recorded potentials in the area of affected tissue.
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DOI：
10.1016/j.clinph.2020.11.014
发表时间：
2021-03
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Sanchez B;Martinsen OG;Freeborn TJ;Furse CM
通讯作者：
Furse CM
DOI：
10.1109/tbme.2021.3063724
发表时间：
2021-10
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Cardoner MMM;Kwon H;Pulido HVG;Nagy J;Rutkove S;Sanchez B
通讯作者：
Sanchez B
影响因子：
4.6
作者：
Lowery, MM;Stoykov, NS;Kuiken, TA
通讯作者：
Kuiken, TA
影响因子：
9.8
作者：
Nagy, J. A.;DiDonato, C. J.;Sanchez, B.
通讯作者：
Sanchez, B.
影响因子：
4.7
作者：
Moffitt, MA;McIntyre, CC
通讯作者：
McIntyre, CC