Generating and regulating immune responses through cutaneous gene delivery.
Generating and regulating immune responses through cutaneous gene delivery.
复制标题
通过皮肤基因传递产生和调节免疫反应。
DOI：
10.1089/104303400750035852
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
FaloJr,LD
中科院分区：
文献类型：
--
作者：
Larregina,AT;FaloJr,LD
The combination of immunization strategies with gene therapy methods constitutes a powerful tool for the purpose of genetic immunization. The cutaneous microenvironment, rich in professional antigen-presenting cells and accessory cells capable of initiating and controlling the intensity of specific immune responses, makes the skin a unique target for the expression of transgenic antigens. The fact that epidermal and dermal dendritic cells can be directly transfected using genetically engineered vectors allowsin vivomanipulation of immune responses by modifying the function of these distinctive antigen-presenting cell populations. Importantly, coexpression of antigenic proteins together with immunostimulatory molecules, and/or adjuvant or leader sequences, makes possible the engineering of antigen-specific immune responses. Even though most of the mechanisms related to DNA immunization remain to be explored, the skin has emerged as an ideal target for evolving genetic vaccination techniques.
登录
查看更多内容
皮肤树突状细胞的起源和迁移特性
DOI：
10.1097/01.all.0000011058.73233.58
发表时间：
2001
影响因子：
2.8
作者：
F. Sallusto
通讯作者：
F. Sallusto
DOI：
10.1073/pnas.96.16.9305
发表时间：
1999-08-03
影响因子：
11.1
作者：
Hartmann, G;Weiner, GJ;Krieg, AM
通讯作者：
Krieg, AM
影响因子：
46.9
作者：
Fan, HR;Lin, Q;Khavari, PA
通讯作者：
Khavari, PA
影响因子：
4.4
作者：
L. Bradley;D. Dalton;M. Croft
通讯作者：
L. Bradley;D. Dalton;M. Croft
皮肤免疫系统：皮肤免疫学和临床免疫皮肤病学，第三版
DOI：
--
发表时间：
2004
期刊：
影响因子：
--
作者：
J. Bos
通讯作者：
J. Bos