Origin and migratory properties of dendritic cells in the skin

Origin and migratory properties of dendritic cells in the skin
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皮肤树突状细胞的起源和迁移特性

DOI:
10.1097/01.all.0000011058.73233.58
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发表时间:
2001
影响因子:
2.8
通讯作者:
F. Sallusto
F. Sallusto
中科院分区:
医学3区
文献类型:
--
作者:
F. Sallusto

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The professional antigen presenting cells of the skin, namely Langerhans cells and dermal dendritic cells, are continuously exposed to environmental stimuli. The population of antigen-carrying dendritic cells that migrates from this site to the draining lymph nodes is highly dynamic, and its density, composition and function changes as a consequence of dendritic cell recruitment and activation in tissues, as well as interactions with T lymphocytes in the specialized lymph node microenvironments. Therefore dendritic cells within the skin are the key regulators of both quantitative and qualitative aspects of immune responses to local antigenic challenge.
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