N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking.
N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking.
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DOI：
10.1111/j.1369-1600.2012.00480.x
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发表时间：
2014-03
影响因子：
3.4
通讯作者：
Weiss F
中科院分区：
文献类型：
--
作者：
Martin-Fardon R;Weiss F
食欲素/下丘脑分泌素（Orexins/hypocretins，Orx/Hcrt）是下丘脑分泌的一种肽类物质，可调节多种生理过程，并被滥用药物所吸收。本研究旨在测试特异性Orx/Hcrt受体-1（Hcrt-r1）拮抗剂SB 334867对由乙醇（EtOH）相关刺激相对于与常规抑制剂相关的刺激（即，SuperSac：由3%葡萄糖和0.125%糖精w/v组成）。SB 334867（1-10 mg/kg，IP）剂量依赖性地减少了由EtOH-而不是SuperSac-相关刺激诱导的恢复。这些发现支持Hcrt-r1在调节EtOH寻求与自然奖励寻求中的不同作用。
Orexins/hypocretins (Orx/Hcrt) are hypothalamic peptides that regulate a wide range of physiological processes and have been shown to be recruited by drugs of abuse. This study was designed to test the effect of the specific Orx/Hcrt receptor-1 (Hcrt-r1) antagonist SB334867 on reinstatement elicited by ethanol (EtOH)-associated stimuli vs. stimuli associated with a conventional reinforcer (i.e., SuperSac: consisting to 3% glucose and 0.125% saccharin w/v). SB334867 (1–10 mg/kg, IP) dose-dependently reduced reinstatement induced by the EtOH- but not SuperSac-associated stimuli. These findings support a differential role of Hcrt-r1 in mediating EtOH seeking vs. natural reward seeking.
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影响因子：
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通讯作者：
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影响因子：
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