Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity.
Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity.
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DOI：
10.3389/fimmu.2014.00570
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发表时间：
2014
影响因子：
7.3
通讯作者：
Lacy P
中科院分区：
文献类型：
--
作者：
Davoine F;Lacy P
嗜酸性粒细胞源自骨髓，在健康个体的血液中以低水平循环。这些颗粒细胞优先离开循环并边缘化到组织，在那里它们参与先天性和适应性免疫的调节。在过敏性炎症等疾病中，炎症灶所在的血液和组织中的嗜酸性粒细胞数量显着增加。嗜酸性粒细胞拥有一系列在细胞激活时释放的免疫调节因子，包括超过 35 种细胞因子、生长因子和趋化因子。与 T 细胞和 B 细胞不同，嗜酸性粒细胞可以在几分钟内快速释放细胞因子以响应刺激。虽然一些细胞因子作为预先形成的介质储存在晶体颗粒和分泌囊泡中，但嗜酸性粒细胞也能够从头合成和分泌这些免疫因子。据推测，协调细胞因子分泌最终步骤的一些分子机制涉及由可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体 (SNARE) 组成的膜融合复合物的结合。这些细胞内受体调节含有一系列分泌蛋白的颗粒和囊泡的释放，其中包括细胞因子和趋化因子。基于人类和动物模型的研究的新证据表明，嗜酸性粒细胞积极参与多种生理/病理过程，例如免疫调节和组织重塑。观察到的嗜酸性粒细胞效应子在健康和疾病中的功能表明嗜酸性粒细胞细胞因子的分泌是一个基本的免疫调节过程。本综述的重点是描述由嗜酸性粒细胞产生的细胞因子、生长因子和趋化因子，并说明导致嗜酸性粒细胞衍生的细胞因子释放的一些细胞内事件。
Eosinophils derive from the bone marrow and circulate at low levels in the blood in healthy individuals. These granulated cells preferentially leave the circulation and marginate to tissues, where they are implicated in the regulation of innate and adaptive immunity. In diseases such as allergic inflammation, eosinophil numbers escalate markedly in the blood and tissues where inflammatory foci are located. Eosinophils possess a range of immunomodulatory factors that are released upon cell activation, including over 35 cytokines, growth factors, and chemokines. Unlike T and B cells, eosinophils can rapidly release cytokines within minutes in response to stimulation. While some cytokines are stored as pre-formed mediators in crystalloid granules and secretory vesicles, eosinophils are also capable of undergoing de novo synthesis and secretion of these immunological factors. Some of the molecular mechanisms that coordinate the final steps of cytokine secretion are hypothesized to involve binding of membrane fusion complexes comprised of soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs). These intracellular receptors regulate the release of granules and vesicles containing a range of secreted proteins, among which are cytokines and chemokines. Emerging evidence from both human and animal model-based research has suggested an active participation of eosinophils in several physiological/pathological processes such as immunomodulation and tissue remodeling. The observed eosinophil effector functions in health and disease implicate eosinophil cytokine secretion as a fundamental immunoregulatory process. The focus of this review is to describe the cytokines, growth factors, and chemokines that are elaborated by eosinophils, and to illustrate some of the intracellular events leading to the release of eosinophil-derived cytokines.
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DOI：
10.1084/jem.171.5.1497
发表时间：
1990-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Conrad DH;Ben-Sasson SZ;Le Gros G;Finkelman FD;Paul WE
通讯作者：
Paul WE
影响因子：
15.9
作者：
COSTA, JJ;MATOSSIAN, K;GALLI, SJ
通讯作者：
GALLI, SJ
DOI：
10.1084/jem.171.3.775
发表时间：
1990-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Nüsse O;Lindau M;Cromwell O;Kay AB;Gomperts BD
通讯作者：
Gomperts BD
影响因子：
1.4
作者：
Allen, JS;Eisma, R;Kreutzer, D
通讯作者：
Kreutzer, D
影响因子：
32.4
作者：
Chu, Van Trung;Beller, Alexander;Berek, Claudia
通讯作者：
Berek, Claudia