Autism as a neural systems disorder: a theory of frontal-posterior underconnectivity.
Autism as a neural systems disorder: a theory of frontal-posterior underconnectivity.
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DOI：
10.1016/j.neubiorev.2012.02.007
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发表时间：
2012-04
影响因子：
8.2
通讯作者：
Varma, Sashank
中科院分区：
文献类型：
--
作者：
Just, Marcel Adam;Keller, Timothy A.;Malave, Vicente L.;Kana, Rajesh K.;Varma, Sashank
自闭症的连通性不足理论将这种障碍归因于额叶和更多后部皮质加工之间的解剖和功能系统连通性降低。在这里，我们回顾了支持这一理论的证据，并提出了一个执行功能任务(伦敦塔)的计算模型，该模型实现了连接不足的假设。我们对以前在伦敦塔任务中对典型个体的表现和脑活动的计算进行了两点修改：(1)额区和顶区之间的通信带宽减少了；(2)后部中心被赋予了更多的执行能力(即更多的自主性，建议根据降低的额后部带宽进行适应)。自闭症模型成功地匹配了fMRI数据中看到的较低的额叶-后部功能连接(较低的激活同步性)，以及提供了对行为反应时间结果的洞察。该理论对神经功能障碍如何导致神经系统障碍和心理障碍以及自闭症广泛而多样的症状提供了统一的解释。
The underconnectivity theory of autism attributes the disorder to lower anatomical and functional systems connectivity between frontal and more posterior cortical processing. Here we review evidence for the theory and present a computational model of an executive functioning task (Tower of London) implementing the assumptions of underconnectivity. We make two modifications to a previous computational account of performance and brain activity in typical individuals in the Tower of London task: (1) the communication bandwidth between frontal and parietal areas was decreased and (2) the posterior centers were endowed with more executive capability (i.e., more autonomy, an adaptation is proposed to arise in response to the lowered frontal-posterior bandwidth). The autism model succeeds in matching the lower frontal-posterior functional connectivity (lower synchronization of activation) seen in fMRI data, as well as providing insight into behavioral response time results. The theory provides a unified account of how a neural dysfunction can produce a neural systems disorder and a psychological disorder with the widespread and diverse symptoms of autism.
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