Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy.
Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy.
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DOI：
10.1016/j.ultrasmedbio.2008.09.002
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发表时间：
2009-02
影响因子：
2.9
通讯作者：
Cain, Charles A.
中科院分区：
文献类型：
--
作者：
Xu, Zhen;Fan, Zhenzhen;Hall, Timothy L.;Winterroth, Frank;Fowlkes, J. Brian;Cain, Charles A.
可以使用连续的高强度超声脉冲（“组织破碎术”）来实现广泛的机械组织分离。组织摧毁术具有许多潜在的医学应用，其中需要非侵入性组织去除（例如，肿瘤消融）。人们担心，组织裂解诱导的组织分离产生的碎片可能会造成栓塞危险。本研究的目的是测量这些组织碎片颗粒的尺寸分布。组织破坏脉冲由513元件1 MHz阵列换能器、18元件750 kHz阵列换能器和788 kHz单元件换能器产生。使用11-25 MPa的峰值负压、3 - 50个循环的脉冲持续时间、100 Hz - 2 kHz的脉冲重复频率。收集由组织破碎术产生的组织碎片颗粒，并使用颗粒测量系统进行测量。在所得样品中，直径< 6 μm的碎片占组织颗粒总数的>99%。其中一个测试参数集产生的最大颗粒直径为54 μm，小于用于防止栓塞的临床过滤器尺寸（100 μm）。使用其他参数集生成的最大颗粒大于60 μm，但使用我们当前的设置无法指定该值。与较长脉冲相比，较短脉冲暴露产生的大组织碎片（>30 μm）百分比较低。这些结果表明，组织碎片的粒度分布是可调的，如果必要的话，通过改变声学参数。
Extensive mechanical tissue fractionation can be achieved using successive high intensity ultrasound pulses (“histotripsy”). Histotripsy has many potential medical applications where non-invasive tissue removal is needed (e.g., tumor ablation). There is a concern that debris generated by histotripsy-induced tissue fractionation might be an embolization hazard. The aim of this study is to measure the size distribution of these tissue debris particles. Histotripsy pulses were produced by a 513-element 1MHz array transducer, an 18-element 750kHz array transducer, and a 788kHz single element transducer. Peak negative pressures of 11-25 MPa, pulse durations of 3 – 50 cycles, pulse repetition frequencies of 100 Hz – 2 kHz were used. Tissue debris particles created by histotripsy were collected and measured with a particle sizing system. In the resulting samples, debris < 6 μm in diameter constituted >99% of the total number of tissue particles. The largest particle generated by one of the parameter sets tested was 54 μm in diameter, which is smaller than the clinic filter size (100 μm) used to prevent embolization. The largest particles generated using other parameter sets were larger than 60 μm, but the value could not be specified using our current setup. Exposures with shorter pulses produced lower percentages of large tissue debris (>30 μm) in comparison to longer pulses. These results suggest that the tissue debris particle size distribution is adjustable by altering acoustic parameters if necessary.
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影响因子：
2.4
作者：
FOWLKES, JB;CARSON, PL;RUBIN, JM
通讯作者：
RUBIN, JM
影响因子：
2.4
作者：
Xu, Z;Fowlkes, JB;Cain, CA
通讯作者：
Cain, CA
DOI：
10.1109/tuffc.2003.1244746
发表时间：
2003-10-01
影响因子：
3.6
作者：
Tran, BC;Seo, J;Cain, CA
通讯作者：
Cain, CA
影响因子：
2.4
作者：
Kaiser, AR;Cain, CA;Jeffers, RJ
通讯作者：
Jeffers, RJ
影响因子：
2.9
作者：
Parsons, JE;Cain, CA;Fowlkes, JB
通讯作者：
Fowlkes, JB