Seasonal variations in gut microbiota and disease course in patients with inflammatory bowel disease.
Seasonal variations in gut microbiota and disease course in patients with inflammatory bowel disease.
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DOI：
10.1371/journal.pone.0283880
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
环境因素与炎症性肠病(IBD)的发病和病程有关。我们之前对大约1100名IBD患者进行的研究显示，一半的患者经历了疾病的季节性恶化。我们调查了IBD患者粪便微生物区系组成的季节性。从2015年11月至2019年4月，在每个季节连续采集IBD门诊患者和健康对照的粪便样本。那些在6个月内接受了全要素饮食或抗生素治疗或有造口的参与者被排除在外。通过16S rRNA测序分析细菌图谱，并比较疾病和季节的变化。共分析了47名参与者的188份粪便样本，其中包括19名克罗恩病(CD)患者、20名溃疡性结肠炎(UC)患者和8名健康对照(HC)。在CD患者中，秋季放线杆菌和TM7的数量均显著高于春季和冬季，而UC患者和HC患者的数量则不明显。此外，放线菌属和TM7属的放线菌属秋季明显多于春季，CD患者的放线菌丰度与TM7-3的丰度呈显著正相关，而UC和HC患者的相关不显著。秋季TM7-3丰度高的CD患者所需的治疗干预明显少于无季节性波动的CD患者。口腔共生放线菌及其共生菌TM7-3在CD患者粪便中随季节发生相关波动，可能影响病程。
Environmental factors are associated with onset and course of inflammatory bowel disease (IBD). Our previous study by about 1,100 IBD patients revealed half of the patients experienced seasonal exacerbation of disease. We investigated the seasonality of fecal microbiota composition of IBD patients. Fecal samples were consecutively collected in each season from IBD outpatients and healthy controls between November 2015 and April 2019. Participants who were treated with full elemental diet or antibiotics within 6 months or had ostomates were excluded. Bacterial profiles were analyzed by 16S rRNA sequencing, and the changes between the diseases and seasons were compared. A total of 188 fecal samples were analyzed from 47 participants comprising 19 Crohn’s disease (CD) patients, 20 ulcerative colitis (UC) patients, and 8 healthy controls (HC). In CD patients, the phylum Actinobacteria and TM7 were both significantly more abundant in autumn than in spring and winter, but not in UC patients and HC. Moreover, the genera Actinomyces, a member of Actinobacteria, and c_TM7-3;o_;f_;g_ (TM7-3), that of TM7, were significantly more abundant in autumn than in spring, and the abundance of Actinomyces was significantly correlated with that of TM7-3 throughout the year in CD patients, but not in UC patients and HC. CD patients with high abundance of TM7-3 in the autumn required significantly fewer therapeutic intervention than those without seasonal fluctuation. Oral commensals Actinomyces and its symbiont TM7-3 were correlatively fluctuated in the feces of CD patients by season, which could affect the disease course.
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影响因子：
4.9
作者：
Kelsen J;Bittinger K;Pauly-Hubbard H;Posivak L;Grunberg S;Baldassano R;Lewis JD;Wu GD;Bushman FD
通讯作者：
Bushman FD
影响因子：
16.6
作者：
Mottawea, Walid;Chiang, Cheng-Kang;Muelbauer, Marcus;Starr, Amanda E.;Butcher, James;Abujamel, Turki;Deeke, Shelley A.;Brandel, Annette;Zhou, Hu;Shokralla, Shadi;Hajibabaei, Mehrdad;Singleton, Ruth;Benchimol, Eric I.;Jobin, Christian;Mack, David R.;Figeys, Daniel;Stintzi, Alain
通讯作者：
Stintzi, Alain
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
DOI：
10.1093/dnares/dsw002
发表时间：
2016-04
期刊：
DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子：
--
作者：
Nishijima S;Suda W;Oshima K;Kim SW;Hirose Y;Morita H;Hattori M
通讯作者：
Hattori M
影响因子：
30.3
作者：
Lewis JD;Chen EZ;Baldassano RN;Otley AR;Griffiths AM;Lee D;Bittinger K;Bailey A;Friedman ES;Hoffmann C;Albenberg L;Sinha R;Compher C;Gilroy E;Nessel L;Grant A;Chehoud C;Li H;Wu GD;Bushman FD
通讯作者：
Bushman FD