Implantable resonators--a technique for repeated measurement of oxygen at multiple deep sites with in vivo EPR.
Implantable resonators--a technique for repeated measurement of oxygen at multiple deep sites with in vivo EPR.
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DOI：
10.1007/978-1-4419-1241-1_38
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发表时间：
2010
影响因子：
--
通讯作者：
Swartz, Harold M.
中科院分区：
文献类型：
--
作者：
Li, Hongbin;Hou, Huagang;Sucheta, Artur;Williams, Benjamin B.;Lariviere, Jean P.;Khan, Md. Nadeem;Lesniewski, Piotr N.;Gallez, Bernard;Swartz, Harold M.
使用植入式谐振器的EPR血氧测定法允许在比表面谐振器更深的部位进行测量（> 80 mm vs. 10 mm），并且在任何深度都具有更高的灵敏度。我们在这里报告的技术，现在使我们能够从多个站点和各种深度的信息的改进的发展。使用简单的磁场梯度来解决来自各个站点的测量。在大鼠脑中，多探针植入谐振器同时测量多个部位的pO2超过6个月，以记录在常氧、缺氧和高氧条件下的pO2。这种技术还有助于在动物的运动部位（如心脏）进行测量，因为顺磁材料相对于敏感小环的取向不会因运动而改变。测量的响应非常快，使得能够在真实的时间内测量生理和病理变化，例如小鼠心脏中的实验性心脏缺血。该技术也非常适用于跟踪肿瘤pO2的变化，包括同时测量肿瘤和邻近正常组织的应用。
EPR oximetry using implantable resonators allow measurements at much deeper sites than are possible with surface resonators (> 80 mm vs. 10 mm) and have greater sensitivity at any depth. We report here the development of an improvement of the technique that now enables us to obtain the information from multiple sites and at a variety of depths. The measurements from the various sites are resolved using a simple magnetic field gradient. In the rat brain multi-probe implanted resonators measured pO2 at several sites simultaneously for over 6 months to record under normoxic, hypoxic and hyperoxic conditions. This technique also facilitates measurements in moving parts of the animal such as the heart, because the orientation of the paramagnetic material relative to the sensitive small loop is not altered by the motion. The measured response is very fast, enabling measurements in real time of physiological and pathological changes such as experimental cardiac ischemia in the mouse heart. The technique also is quite useful for following changes in tumor pO2, including applications with simultaneous measurements in tumors and adjacent normal tissues.
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影响因子：
2.2
作者：
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通讯作者：
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影响因子：
120.7
作者：
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通讯作者：
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影响因子：
12.6
作者：
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通讯作者：
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