The suppressive role of SOX7 in hepatocarcinogenesis.
The suppressive role of SOX7 in hepatocarcinogenesis.
复制标题
SOX7在肝癌发生中的抑制作用
DOI：
10.1371/journal.pone.0097433
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Min Z
中科院分区：
文献类型：
--
作者：
Wang C;Guo Y;Wang J;Min Z
SOX 7是一种转录因子，介导多种发育过程。然而，其在肝细胞癌（HCC）中的作用仍不清楚。在这里，我们评估了SOX 7在肝癌发生中的作用。我们发现肝癌组织中SOX 7的mRNA和蛋白表达水平均低于非肿瘤组织，且SOX 7的表达与肿瘤大小呈负相关。SOX 7表达在四种HCC细胞系（SMMC-7721、Hep 3B、HepG 2和Huh 7）中也降低。过表达SOX 7可抑制肝癌细胞的生长，使细胞阻滞于G1期至S期。在SOX 7过表达细胞中，两个细胞周期启动子cyclin D1和c-myc表达下调。此外，cyclin D1或c-myc的异位表达可逆转SOX 7诱导的G1期至S期阻滞。此外，过表达SOX 7抑制肿瘤形成，下调细胞周期蛋白D1和c-myc在体内。增殖标记物Ki-67的表达在SOX 7过表达的肿瘤中也降低。总之，我们的研究表明，SOX 7在肝癌发生中起着重要的抑制作用，并可能成为肝癌治疗的新靶点。
SOX7 is a transcription factor mediating various developmental processes. However, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we assessed the role of SOX7 in hepatocarcinogenesis. We found HCC samples exhibited lower levels of SOX7 mRNA and protein expression than non-tumor samples, and the expression of SOX7 was negatively correlated with tumor size. SOX7 expression was also reduced in four HCC cell lines (SMMC-7721, Hep3B, HepG2 and Huh 7). Overexpression of SOX7 could inhibit HCC cell growth, with G1to S phase arrest. In SOX7-overexpression cells, cyclin D1 and c-myc, two cell cycle promoters, were down-regulated. Moreover, ectopic expression of cyclin D1 or c-myc could override G1 to S pahse arrest induced by SOX7. Furthermore, overexpression of SOX7 suppressed tumor formation with down-regulation of cyclin D1 and c-myc in vivo. The expression of Ki-67, a proliferation marker, was also reduced in SOX7-overexpression tumors. Taken together, our study suggests that SOX7 plays an important inhibitory role in hepatocarcinogenesis, and might be a novel target for HCC therapy.
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影响因子：
2
作者：
Stovall DB;Cao P;Sui G
通讯作者：
Sui G
影响因子：
5.2
作者：
Zimonjic DB;Popescu NC
通讯作者：
Popescu NC
影响因子：
3.7
作者：
EMI, M;FUJIWARA, Y;NAKAMURA, Y
通讯作者：
NAKAMURA, Y
DOI：
10.1046/j.1440-1746.2003.02973.x
发表时间：
2003-03-01
影响因子：
4.1
作者：
Cui, J;Zhou, XD;Romeih, M
通讯作者：
Romeih, M
影响因子：
3.7
作者：
Ye X;Guo Y;Zhang Q;Chen W;Hua X;Liu W;Yang Y;Chen G
通讯作者：
Chen G