Effects of diffusion time on short-range hyperpolarized (3)He diffusivity measurements in emphysema.
Effects of diffusion time on short-range hyperpolarized (3)He diffusivity measurements in emphysema.
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DOI：
10.1002/jmri.21912
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发表时间：
2009-10
影响因子：
4.4
通讯作者：
Conradi, Mark S.
中科院分区：
文献类型：
--
作者：
Gierada, David S.;Woods, Jason C.;Bierhals, Andrew J.;Bartel, Seth T.;Ritter, Jon H.;Choong, Cliff K.;Das, Nitin A.;Hong, Cheng;Pilgram, Thomas K.;Chang, Yulin V.;Jacob, Richard E.;Hogg, James C.;Battafarano, Richard J.;Cooper, Joel D.;Meyers, Bryan F.;Patterson, G. Alexander;Yablonskiy, Dmitriy A.;Conradi, Mark S.
描述扩散时间对各种肺气肿严重程度的短程超极化3 He MR扩散测量的影响。对18例不同程度肺气肿患者的19个肺或肺叶进行了3 He弥散成像，采用3种弥散时间（1.6 msec、5 msec和10 msec），恒定B值。肺气肿严重程度量化为平均表观扩散系数（ADC）和ADC高于0.30-0.55 cm 2/sec多个阈值（ADC指数）的像素百分比。在10例受试者的10份肺标本中获得定量组织学（平均线性截距）。扩散时间为1.6、5.0和10.0 msec的平均ADC分别为0.46、0.40和0.37 cm 2/sec（P <0.0001，ANOVA）。扩散时间对ADC值的影响与ADC值大小无关。在所有扩散时间点，ADC值与平均线性截距相关（r=0.91-0.94，P<0.001），ADC指数与平均线性截距相关（r=0.78-0.92，P<0.01）。弥散时间延长时ADC值的降低与肺气肿的严重程度无关。所有扩散时间下的ADC与定量组织学之间的强相关性表明ADC是肺气肿的可靠指标。
To characterize the effect of diffusion time on short-range hyperpolarized 3He MR diffusion measurements across a wide range of emphysema severity. 3He diffusion MR imaging was performed on 19 lungs or lobes resected from 18 subjects with varying degrees of emphysema using 3 diffusion times (1.6 msec, 5 msec, and 10 msec) at constant b value. Emphysema severity was quantified as the mean apparent diffusion coefficient (ADC) and as the percentage of pixels with ADC higher than multiple thresholds from 0.30–0.55 cm2/sec (ADC index). Quantitative histology (mean linear intercept) was obtained in 10 of the lung specimens from 10 of the subjects. The mean ADCs with diffusion times of 1.6, 5.0, and 10.0 msec were 0.46, 0.40, and 0.37 cm2/sec, respectively (P <0.0001, ANOVA). There was no relationship between the ADC magnitude and the effect of diffusion time on ADC values. Mean linear intercept correlated with ADC (r=0.91–0.94, P<0.001) and ADC index (r=0.78–0.92, P<0.01) at all diffusion times. Decreases in ADC with longer diffusion time were unrelated to emphysema severity. The strong correlations between the ADC at all diffusion times tested and quantitative histology demonstrate that the ADC is a robust measure of emphysema.
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影响因子：
2.8
作者：
MITTERMAYER, C;WYBITUL, K;RIEDE, UN
通讯作者：
RIEDE, UN
影响因子：
2.2
作者：
Sukstanskii, A. L.;Yablonskiy, D. A.
通讯作者：
Yablonskiy, D. A.
DOI：
10.1073/pnas.052594699
发表时间：
2002-03-05
影响因子：
11.1
作者：
Yablonskiy, DA;Sukstanskii, AL;Conradi, MS
通讯作者：
Conradi, MS
影响因子：
4.8
作者：
Fain, SB;Altes, TA;Owers-Bradley, J
通讯作者：
Owers-Bradley, J
影响因子：
4.8
作者：
Mugler, John P., III;Wang, Chengbo;Altes, Talissa A.
通讯作者：
Altes, Talissa A.