The Making and Breaking of RNAs: Dynamics of Rhythmic RNA Expression in Mammals.
The Making and Breaking of RNAs: Dynamics of Rhythmic RNA Expression in Mammals.
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DOI：
10.1177/0748730420957498
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发表时间：
2020-12
影响因子：
3.5
通讯作者：
Kojima, Shihoko
中科院分区：
文献类型：
--
作者：
Unruh, Benjamin A.;Kojima, Shihoko
在过去的20年里，有节奏地表达的mRNA的鉴定和表征一直是一个活跃的研究领域，因为这些mRNA被认为在广泛的生物过程中产生日常节奏。昼夜节律转录组研究使用成熟mRNA作为主要读数，并主要集中在节律性RNA合成作为节律性mRNA表达的调控机制。然而，RNA合成、RNA降解或两者的组合必须是有节奏的，以驱动有节奏的RNA谱，目前还不清楚有节奏的合成在多大程度上导致有节奏的RNA谱。此外，昼夜节律RNA表达也常常是组织特异性的。尽管少数基因在所有或大多数组织中循环，但其他基因仅在某些组织中具有节律性，即使相同的核心时钟机制被认为控制所有组织中的RNA节律。本文综述了RNA合成和降解的动态规律，并讨论了这些步骤如何共同决定RNA积累的节律性、相位和幅度。特别是，我们强调了RNA降解在驱动组织特异性RNA节律中的可能作用。通过统一的实验和理论研究的结果，我们将提供一个全面的概述如何节奏的基因表达可以实现，以及每个监管步骤如何有助于组织特异性的昼夜节律转录组输出哺乳动物。
The identification and characterization of rhythmically expressed mRNAs have been an active area of research over the past 20 years, as these mRNAs are believed to produce the daily rhythms in a wide range of biological processes. Circadian transcriptome studies have used mature mRNA as a primary readout and focused largely on rhythmic RNA synthesis as a regulatory mechanism underlying rhythmic mRNA expression. However, RNA synthesis, RNA degradation, or a combination of both must be rhythmic to drive rhythmic RNA profiles, and it is still unclear to what extent rhythmic synthesis leads to rhythmic RNA profiles. In addition, circadian RNA expression is also often tissue specific. Although a handful of genes cycle in all or most tissues, others are rhythmic only in certain tissues, even though the same core clock mechanism is believed to control the rhythmic RNA profiles in all tissues. This review focuses on the dynamics of rhythmic RNA synthesis and degradation and discusses how these steps collectively determine the rhythmicity, phase, and amplitude of RNA accumulation. In particular, we highlight a possible role of RNA degradation in driving tissue-specific RNA rhythms. By unifying findings from experimental and theoretical studies, we will provide a comprehensive overview of how rhythmic gene expression can be achieved and how each regulatory step contributes to tissue-specific circadian transcriptome output in mammals.
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影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
Panda S
影响因子：
46.9
作者：
Gaidatzis, Dimos;Burger, Lukas;Stadler, Michael B.
通讯作者：
Stadler, Michael B.
DOI：
10.1038/s41580-018-0028-8
发表时间：
2018-10
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Haberle V;Stark A
通讯作者：
Stark A
影响因子：
16.6
作者：
Alkallas R;Fish L;Goodarzi H;Najafabadi HS
通讯作者：
Najafabadi HS
影响因子：
10.5
作者：
Beytebiere, Joshua R.;Trott, Alexandra J.;Menet, Jerome S.
通讯作者：
Menet, Jerome S.