Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult.
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult.
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DOI：
10.1016/j.spen.2012.02.002
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发表时间：
2012-09
影响因子：
2.7
通讯作者：
Bonthius, Daniel J.
中科院分区：
文献类型：
--
作者：
Bonthius, Daniel J.
淋巴细胞性脉络丛脑膜炎病毒（LCMV）是人类神经系统疾病的重要病因。LCMV主要由野鼠携带和分泌，覆盖很大的地理范围，感染大量人群。当人类接触受感染小鼠的分泌物时，就会获得LCMV疾病。由于它具有很强的嗜神经性，LCMV感染的临床体征和症状大多是神经系统的。当病毒是后天获得的儿童或成人，临床表现通常是无菌性脑膜炎。大多数在儿童或成年期间获得LCMV感染的人在几周内有中度症状，但完全康复。一种更严重的疾病发生在产前感染时。LCMV可以感染胎儿的大脑和视网膜，在那里它会导致实质性的损伤和永久性的功能障碍。在所有有先天性感染证据的婴儿中，特别是那些有突出神经系统体征的婴儿，如小脑畸形、脑室周围钙化和脑积水，都应考虑LCMV感染的可能性。
Lymphocytic choriomeningitis virus (LCMV) is an important cause of neurologic disease in humans. Carried and secreted principally by wild mice, LCMV covers a large geographic range and infects great numbers of people. Humans acquire LCMV disease when they come into contact with the secretions of infected mice. Because it has a strong neurotropism, the clinical signs and symptoms of LCMV infection are mostly neurologic. When the virus is acquired postnatally by children or adults, the clinical manifestations are usually those of aseptic meningitis. Most people who acquire LCMV infection during childhood or adulthood are moderately symptomatic for several weeks, but have a full recovery. A much more severe disease ensues when the infection occurs prenatally. LCMV can infect the fetal brain and retina, where it leads to substantial injury and permanent dysfunction. The possibility of LCMV infection should be considered in all babies with evidence of congenital infection, especially those with prominent neurologic signs, such as microencephaly, periventricular calcifications, and hydrocephalus.
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DOI：
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发表时间：
1992-07-01
影响因子：
3.3
作者：
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发表时间：
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