The role of dendritic cells in CNS autoimmunity.
The role of dendritic cells in CNS autoimmunity.
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DOI：
10.1007/s00109-010-0607-4
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发表时间：
2010-06
影响因子：
4.7
通讯作者：
Wiendl, Heinz
中科院分区：
文献类型：
--
作者：
Zozulya, Alla L.;Clarkson, Benjamin D.;Ortler, Sonja;Fabry, Zsuzsanna;Wiendl, Heinz
关键词：
多发性硬化（MS）是一种慢性免疫介导的中枢神经系统（CNS）脱髓鞘疾病。临床和组织病理学特征表明，炎症病因涉及常驻CNS先天细胞以及入侵的适应性免疫细胞。致脑炎髓鞘反应性T细胞参与炎症级联反应的启动，最终导致脱髓鞘和轴突损伤（MS的组织学标志）。树突状细胞（DC）最近已成为这种免疫病理级联反应的关键调节剂，这得到了人类和实验性疾病模型研究的支持。在一个这样的模型中，实验性自身免疫性脑脊髓炎（EAE），CNS微血管相关DC已被证明对于髓鞘反应性T细胞的局部抗原识别是必需的。此外，来自CNS和相关神经系统的DC的功能状态和房室分布似乎是EAE的诱导和效应阶段的限制因素。此外，DC调节和平衡致脑炎性T细胞和调节性T细胞向CNS组织的募集。这种能力受到DC表面共刺激或共抑制分子表达的严重影响。DC在T细胞之前在CNS中积累并且可以指导T细胞应答的事实表明它们是CNS自身免疫结果的关键决定因素。在这里，我们提供了一个全面的审查，我们了解CNS衍生的DC及其相关性神经炎症的最新进展。
Multiple sclerosis (MS) is a chronic immune-mediated, central nervous system (CNS) demyelinating disease. Clinical and histopathological features suggest an inflammatory etiology involving resident CNS innate cells as well as invading adaptive immune cells. Encephalitogenic myelin-reactive T cells have been implicated in the initiation of an inflammatory cascade, eventually resulting in demyelination and axonal damage (the histological hallmarks of MS). Dendritic cells (DC) have recently emerged as key modulators of this immunopathological cascade, as supported by studies in humans and experimental disease models. In one such model, experimental autoimmune encephalomyelitis (EAE), CNS microvessel-associated DC have been shown to be essential for local antigen recognition by myelin-reactive T cells. Moreover, the functional state and compartmental distribution of DC derived from CNS and associated lymphatics seem to be limiting factors in both the induction and effector phases of EAE. Moreover, DC modulate and balance the recruitment of encephalitogenic and regulatory T cells into CNS tissue. This capacity is critically influenced by DC surface expression of co-stimulatory or co-inhibitory molecules. The fact that DC accumulate in the CNS before T cells and can direct T-cell responses suggests that they are key determinants of CNS autoimmune outcomes. Here we provide a comprehensive review of recent advances in our understanding of CNS-derived DC and their relevance to neuroinflammation.
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影响因子：
15.3
作者：
Inaba, K.;Witmer-Pack, M.;Inaba, M.;Hathcock, K. S.;Sakuta, H.;Azuma, M.;Yagita, H.;Okumura, K.;Linsley, P. S.;Ikehara, S.;Muramatsu, S.;Hodes, R. J.;Steinman, R. M.
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Steinman, R. M.
影响因子：
2.7
作者：
Berger, CE;Kröner, A;Engel, A
通讯作者：
Engel, A
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4.4
作者：
de Vos, AF;van Meurs, M;Laman, JD
通讯作者：
Laman, JD
影响因子：
82.9
作者：
Greter, M;Heppner, FL;Becher, B
通讯作者：
Becher, B
影响因子：
3.3
作者：
Huang, YM;Xiao, BG;Link, H
通讯作者：
Link, H