Prostate cancer incidence as an iceberg.
Prostate cancer incidence as an iceberg.
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DOI：
10.1007/s10654-017-0265-8
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发表时间：
2017-06
影响因子：
13.6
通讯作者：
Wilson KM
中科院分区：
文献类型：
--
作者：
Mucci LA;Pernar CH;Peisch S;Gerke T;Wilson KM
前列腺癌的发病原因有哪些？在全球范围内，2015年有160万男性被诊断患有前列腺癌[1]，其发病率比前10年显著上升了66%。它是103个国家中男性最常诊断的癌症，但不同国家和人群的年龄调整发病率存在显著差异。一组流行病学家可能只同意以下风险因素为“既定”：年龄较大，非洲血统和前列腺癌阳性家族史[2]。它是估计遗传率第二高的癌症[3]，全基因组关联研究现已证实在种族多样性人群中有180多个遗传风险基因座[4，5]。较高的身高也是总前列腺癌的可能风险因素[6]。考虑到这种癌症的全球负担，令人担忧的是，总体上前列腺癌发病率没有确认的可改变的风险因素，这使我们对该疾病的病因学理解变得复杂。
The epidemiology of prostate cancer is enigmatic. Globally, 1.6 million men were diagnosed with prostate cancer in 2015 [1], a notable 66% rise in its incidence from the prior 10 years. It is the most commonly diagnosed cancer in men in 103 countries, yet there is marked variation in age-adjusted incidence rates across countries and populations. A panel of epidemiologists are likely to agree only on the following risk factors as ‘‘established’’: older age, African ancestry, and positive family history of prostate cancer [2]. It is the cancer with the second-highest estimated heritability [3], and genome wide association studies have now confirmed more than 180 inherited genetic risk loci in ethnically diverse populations [4, 5]. Taller height is also a probable risk factor for total prostate cancer [6]. Given the global burden of this cancer, it is alarming that there are no confirmed modifiable risk factors for prostate cancer incidence overall, which complicates our etiological understanding of the disease.
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影响因子：
28.4
作者：
Global Burden of Disease Cancer Collaboration;Fitzmaurice C;Allen C;Barber RM;Barregard L;Bhutta ZA;Brenner H;Dicker DJ;Chimed-Orchir O;Dandona R;Dandona L;Fleming T;Forouzanfar MH;Hancock J;Hay RJ;Hunter-Merrill R;Huynh C;Hosgood HD;Johnson CO;Jonas JB;Khubchandani J;Kumar GA;Kutz M;Lan Q;Larson HJ;Liang X;Lim SS;Lopez AD;MacIntyre MF;Marczak L;Marquez N;Mokdad AH;Pinho C;Pourmalek F;Salomon JA;Sanabria JR;Sandar L;Sartorius B;Schwartz SM;Shackelford KA;Shibuya K;Stanaway J;Steiner C;Sun J;Takahashi K;Vollset SE;Vos T;Wagner JA;Wang H;Westerman R;Zeeb H;Zoeckler L;Abd-Allah F;Ahmed MB;Alabed S;Alam NK;Aldhahri SF;Alem G;Alemayohu MA;Ali R;Al-Raddadi R;Amare A;Amoako Y;Artaman A;Asayesh H;Atnafu N;Awasthi A;Saleem HB;Barac A;Bedi N;Bensenor I;Berhane A;Bernabé E;Betsu B;Binagwaho A;Boneya D;Campos-Nonato I;Castañeda-Orjuela C;Catalá-López F;Chiang P;Chibueze C;Chitheer A;Choi JY;Cowie B;Damtew S;das Neves J;Dey S;Dharmaratne S;Dhillon P;Ding E;Driscoll T;Ekwueme D;Endries AY;Farvid M;Farzadfar F;Fernandes J;Fischer F;G/Hiwot TT;Gebru A;Gopalani S;Hailu A;Horino M;Horita N;Husseini A;Huybrechts I;Inoue M;Islami F;Jakovljevic M;James S;Javanbakht M;Jee SH;Kasaeian A;Kedir MS;Khader YS;Khang YH;Kim D;Leigh J;Linn S;Lunevicius R;El Razek HMA;Malekzadeh R;Malta DC;Marcenes W;Markos D;Melaku YA;Meles KG;Mendoza W;Mengiste DT;Meretoja TJ;Miller TR;Mohammad KA;Mohammadi A;Mohammed S;Moradi-Lakeh M;Nagel G;Nand D;Le Nguyen Q;Nolte S;Ogbo FA;Oladimeji KE;Oren E;Pa M;Park EK;Pereira DM;Plass D;Qorbani M;Radfar A;Rafay A;Rahman M;Rana SM;Søreide K;Satpathy M;Sawhney M;Sepanlou SG;Shaikh MA;She J;Shiue I;Shore HR;Shrime MG;So S;Soneji S;Stathopoulou V;Stroumpoulis K;Sufiyan MB;Sykes BL;Tabarés-Seisdedos R;Tadese F;Tedla BA;Tessema GA;Thakur JS;Tran BX;Ukwaja KN;Uzochukwu BSC;Vlassov VV;Weiderpass E;Wubshet Terefe M;Yebyo HG;Yimam HH;Yonemoto N;Younis MZ;Yu C;Zaidi Z;Zaki MES;Zenebe ZM;Murray CJL;Naghavi M
通讯作者：
Naghavi M
影响因子：
30.8
作者：
Eeles, Rosalind A.;Al Olama, Ali Amin;Benlloch, Sara;Saunders, Edward J.;Leongamornlert, Daniel A.;Tymrakiewicz, Malgorzata;Ghoussaini, Maya;Luccarini, Craig;Dennis, Joe;Jugurnauth-Little, Sarah;Dadaev, Tokhir;Neal, David E.;Hamdy, Freddie C.;Donovan, Jenny L.;Muir, Ken;Giles, Graham G.;Severi, Gianluca;Wiklund, Fredrik;Gronberg, Henrik;Haiman, Christopher A.;Schumacher, Fredrick;Henderson, Brian E.;Le Marchand, Loic;Lindstrom, Sara;Kraft, Peter;Hunter, David J.;Gapstur, Susan;Chanock, Stephen J.;Berndt, Sonja I.;Albanes, Demetrius;Andriole, Gerald;Schleutker, Johanna;Weischer, Maren;Canzian, Federico;Riboli, Elio;Key, Tim J.;Travis, Ruth C.;Campa, Daniele;Ingles, Sue A.;John, Esther M.;Hayes, Richard B.;Pharoah, Paul D. P.;Pashayan, Nora;Khaw, Kay-Tee;Stanford, Janet L.;Ostrander, Elaine A.;Signorello, Lisa B.;Thibodeau, Stephen N.;Schaid, Dan;Maier, Christiane;Vogel, Walther;Kibel, Adam S.;Cybulski, Cezary;Lubhiski, Jan;Cannon-Albright, Lisa;Brenner, Hermann;Park, Jong Y.;Kaneva, Radka;Batra, Jyotsna;Spurdle, Amanda B.;Clements, Judith A.;Teixeira, Manuel R.;Dicks, Ed;Lee, Andrew;Dunning, Alison M.;Baynes, Caroline;Conroy, Don;Maranian, Melanie J.;Ahmed, Shahana;Govindasami, Koveela;Guy, Michelle;Wilkinson, Rosemary A.;Sawyer, Emma J.;Morgan, Angela;Dearnaley, David P.;Horwich, Alan;Huddart, Robert A.;Khoo, Vincent S.;Parker, Christopher C.;Van As, Nicholas J.;Woodhouse, Christopher J.;Thompson, Alan;Dudderidge, Tim;Ogden, Chris;Cooper, Colin S.;Lophatananon, Artitaya;Cox, Angela;Southey, Melissa C.;Hopper, John L.;English, Dallas R.;Aly, Markus;Adolfsson, Jan;Xu, Jiangfeng;Zheng, Siqun L.;Yeager, Meredith;Kaaks, Rudolf;Diver, W. Ryan;Gaudet, Mia M.;Stern, Mariana C.;Corral, Roman;Joshi, Amit D.;Shahabi, Ahva;Wahlfors, Tiina;Tammela, Teuvo L. J.;Auvinen, Anssi;Virtamo, Jarmo;Klarskov, Peter;Nordestgaard, Borge G.;Roder, M. Andreas;Nielsen, Sune F.;Bojesen, Stig E.;Siddiq, Afshan;FitzGerald, Liesel M.;Kolb, Suzanne;Kwon, Erika M.;Karyadi, Danielle M.;Blot, William J.;Zheng, Wei;Cai, Qiuyin;McDonnell, Shannon K.;Rinckleb, Antje E.;Drake, Bettina;Colditz, Graham;Wokolorczyk, Dominika;Stephenson, Robert A.;Teerlink, Craig;Muller, Heiko;Rothenbacher, Dietrich;Sellers, Thomas A.;Lin, Hui-Yi;Slavov, Chavdar;Mitev, Vanio;Lose, Felicity;Srinivasan, Srilakshmi;Maia, Sofia;Paulo, Paula;Lange, Ethan;Cooney, Kathleen A.;Antoniou, Antonis C.;Vincent, Daniel;Bacot, Francois;Tessier, Daniel C.;Kote-Jarai, Zsofia;Easton, Douglas F.
通讯作者：
Easton, Douglas F.
影响因子：
8.4
作者：
Ciatto, S;Gervasi, G;Zappa, M
通讯作者：
Zappa, M
影响因子：
30.8
作者：
Al Olama, Ali Amin;Kote-Jarai, Zsofia;Berndt, Sonja I.;Conti, David V.;Schumacher, Fredrick;Han, Ying;Benlloch, Sara;Hazelett, Dennis J.;Wang, Zhaoming;Saunders, Ed;Leongamornlert, Daniel;Lindstrom, Sara;Jugurnauth-Little, Sara;Dadaev, Tokhir;Tymrakiewicz, Malgorzata;Stram, Daniel O.;Rand, Kristin;Wan, Peggy;Stram, Alex;Sheng, Xin;Pooler, Loreall C.;Park, Karen;Xia, Lucy;Tyrer, Jonathan;Kolonel, Laurence N.;Le Marchand, Loic;Hoover, Robert N.;Machiela, Mitchell J.;Yeager, Merideth;Burdette, Laurie;Chung, Charles C.;Hutchinson, Amy;Yu, Kai;Goh, Chee;Ahmed, Mahbubl;Govindasami, Koveela;Guy, Michelle;Tammela, Teuvo L. J.;Auvinen, Anssi;Wahlfors, Tlina;Schleutker, Johanna;Visakorpi, Tapio;Leinonen, Katri A.;Xu, Jianfeng;Aly, Markus;Donovan, Jenny;Travis, Ruth C.;Key, Tim J.;Siddiq, Afshan;Canzian, Federico;Khaw, Kay-Tee;Takahashi, Atsushi;Kubo, Michiaki;Pharoah, Paul;Pashayan, Nora;Weischer, Maren;Nordestgaard, Borge G.;Nielsen, Sune F.;Klarskov, Peter;Roder, Martin Andreas;Iversen, Peter;Thibodeau, Stephen N.;McDonnell, Shannon K.;Schaid, Daniel J.;Stanford, Janet L.;Kolb, Suzanne;Holt, Sarah;Knudsen, Beatrice;Coll, Antonio Hurtado;Gapstur, Susan M.;Diver, W. Ryan;Stevens, Victoria L.;Maier, Christiane;Luedeke, Manuel;Herkommer, Kathleen;Rinckleb, Antje E.;Strom, Sara S.;Pettaway, Curtis;Yeboah, Edward D.;Tettey, Yao;Biritwum, Richard B.;Adjei, Andrew A.;Tay, Evelyn;Truelove, Ann;Niwa, Shelley;Choklcalingam, Anand P.;Cannon-Albright, Lisa;Cybulski, Cezary;Wokolorczyk, Dominika;Kluzniak, Wojciech;Park, Jong;Sellers, Thomas;Lin, Hui-Yi;Isaacs, William B.;Partin, Alan W.;Brenner, Hermann;Dieffenbach, Aida Karina;Stegmaier, Christa;Chen, Constance;Giovannucci, Edward L.;Ma, Jing;Stampfer, Meir;Penney, Kathryn L.;Mucci, Lorelei;John, Esther M.;Ingles, Sue A.;Kittles, Rick A.;Murphy, Adam B.;Pandha, Hardev;Michael, Agnieszka;Kierzek, Andrzej M.;Blot, William;Signorello, Lisa B.;Zheng, Wei;Albanes, Demetrius;Virtamo, Jarmo;Weinstein, Stephanie;Nemesure, Barbara;Carpten, John;Leske, Cristina;Wu, Suh-Yuh;Hennis, Anselm;Kibel, Adam S.;Rybicki, Benjamin A.;Neslund-Dudas, Christine;Hsing, Ann W.;Chu, Lisa;Goodman, Phyllis J.;Klein, Eric A.;Zheng, S. Lilly;Batra, Jyotsna;Clements, Judith;Spurdle, Amanda;Teixeira, Manuel R.;Paulo, Paula;Maia, Sofia;Slavov, Chavdar;Kaneva, Radka;Mitev, Vanio;Witte, John S.;Casey, Graham;Gillanders, Elizabeth M.;Seminara, Daniella;Riboli, Elio;Hamdy, Freddie C.;Coetzee, Gerhard A.;Li, Qiyuan;Freedman, Matthew L.;Hunter, David J.;Muir, Kenneth;Gronberg, Henrik;Nea, David E.;Southey, Melissa;Giles, Graham G.;Severi, Gianluca;Cook, Michael B.;Nakagawa, Hidewaki;Wiklund, Fredrik;Kraft, Peter;Chanock, Stephen J.;Henderson, Brian E.;Easton, Douglas F.;Eeles, Rosalind A.;Haiman, Christopher A.
通讯作者：
Haiman, Christopher A.
影响因子：
13.6
作者：
Valberg M;Grotmol T;Tretli S;Veierød MB;Moger TA;Devesa SS;Aalen OO
通讯作者：
Aalen OO