Body mass index and two-year change of in vivo Alzheimer's disease pathologies in cognitively normal older adults.
Body mass index and two-year change of in vivo Alzheimer's disease pathologies in cognitively normal older adults.
复制标题
DOI：
10.1186/s13195-023-01259-w
复制
发表时间：
2023-06-13
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
低体重指数（BMI）或晚年体重不足状态与痴呆或阿尔茨海默病（AD）的风险增加有关。然而，尚未研究晚期BMI与体内AD病理学的前瞻性纵向变化之间的关系。这项前瞻性纵向研究是韩国阿尔茨海默病早期诊断和预测脑老化研究（KBASE）的一部分。共有194名认知正常的老年人被纳入分析。测量基线时的BMI，并将PET成像上脑Aβ和tau沉积的两年变化作为主要结局。线性混合效应（LME）模型被用来检查晚年BMI和AD神经病理学生物标志物的纵向变化之间的关系。基线时较低的BMI与2年内AD特征区域tau沉积的增加显著相关（β，-0.018; 95% CI，-0.028至-0.004; p = .008），相反，BMI与总体Aβ沉积的两年变化无关。（β，0.0002; 95% CI，-0.003至0.002，p = .671）。对每种性别进行的额外探索性分析显示，基线BMI较低与男性中tau沉积增加较大相关（β，-0.027; 95% CI，-0.046至-0.009; p = 0.007），但女性中不相关。研究结果表明，晚年较低的BMI可能预测或有助于认知未受损的老年人在随后几年中tau病理学的进展。
Low body mass index (BMI) or underweight status in late life is associated with an increased risk of dementia or Alzheimer’s disease (AD). However, the relationship between late-life BMI and prospective longitudinal changes of in-vivo AD pathology has not been investigated. This prospective longitudinal study was conducted as part of the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE). A total of 194 cognitive normal older adults were included in the analysis. BMI at baseline was measured, and two-year changes in brain Aβ and tau deposition on PET imaging were used as the main outcomes. Linear mixed-effects (LME) models were used to examine the relationships between late-life BMI and longitudinal change in AD neuropathological biomarkers. A lower BMI at baseline was significantly associated with a greater increase in tau deposition in AD-signature region over 2 years (β, -0.018; 95% CI, -0.028 to -0.004; p = .008), In contrast, BMI was not related to two-year changes in global Aβ deposition (β, 0.0002; 95% CI, -0.003 to 0.002, p = .671). An additional exploratory analysis for each sex showed lower baseline BMI was associated with greater increases in tau deposition in males (β, -0.027; 95% CI, -0.046 to -0.009; p = 0.007), but not in females. The findings suggest that lower BMI in late-life may predict or contribute to the progression of tau pathology over the subsequent years in cognitively unimpaired older adults.
登录
查看更多内容
DOI：
10.1001/jama.2017.3090
发表时间：
2017-04-11
期刊：
JAMA
影响因子：
--
作者：
Gottesman RF;Schneider AL;Zhou Y;Coresh J;Green E;Gupta N;Knopman DS;Mintz A;Rahmim A;Sharrett AR;Wagenknecht LE;Wong DF;Mosley TH
通讯作者：
Mosley TH
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
DOI：
10.3233/jad-2010-1308
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Greco SJ;Bryan KJ;Sarkar S;Zhu X;Smith MA;Ashford JW;Johnston JM;Tezapsidis N;Casadesus G
通讯作者：
Casadesus G
影响因子：
2.7
作者：
Kim, Ji Yang;Park, Joon Hyuk;Woo, Jong Inn
通讯作者：
Woo, Jong Inn
影响因子：
9.9
作者：
Jack, Clifford R., Jr.;Wiste, Heather J.;Petersen, Ronald C.
通讯作者：
Petersen, Ronald C.