Proliferation genes in lung development associated with the prognosis of lung adenocarcinoma but not squamous cell carcinoma.
Proliferation genes in lung development associated with the prognosis of lung adenocarcinoma but not squamous cell carcinoma.
复制标题
DOI：
10.1111/cas.13456
复制
发表时间：
2018-03
期刊：
影响因子：
5.7
通讯作者：
Cheng S
中科院分区：
文献类型：
--
作者：
Li P;Zhang L;Yu X;Tong R;Di X;Mao Y;Gao Y;Zhang K;Feng L;Cheng S
胚胎发育和肿瘤发生之间有许多相似之处，基因表达谱显示发育过程中的基因特征与不同癌症的临床表型之间存在一定的相关性。本课课组之前报道了人类肺发育的基因表达谱，其中一组增殖相关基因（PTN1基因）的表达在肺发育过程中稳步下降。在这里，我们检测了PTN1基因在5个独立肺腺癌（ADC）和5个肺非独立鳞状细胞癌（SCC）微阵列数据集中的预后价值，发现PTN1基因的表达水平与肺ADC的生存相关，而与肺SCC无关。所有肺ADC数据集都包含一组来自PTN1基因的高度相关基因，但肺SCC数据集没有类似的基因集。我们从5个肺ADC数据集中的PTN1基因中鉴定出63个独特的核心基因：其中17个核心基因出现在至少4个肺ADC数据集中，并且17个相应的蛋白在肺ADC中明显比在肺SCC中相互作用更强。此外，17个核心基因中有16个在细胞周期的G2/M期起主要作用。这些数据表明，肺发育中的增殖相关基因对肺ADC具有重要的预后价值；17个核心基因的协同作用在肺ADC预后中起重要作用。这些基因可能对肺ADC的治疗和预后有重要的临床意义。
There are many similarities between embryonic development and tumorigenesis, and gene expression profiles show that certain correlations exist between the gene signature during development and the clinical phenotypes of different cancers. Our group previously reported the gene expression profiles of human lung development, and the expression of one group of proliferation‐related genes (PTN1 genes) steadily decreased during lung development. Here, we examined the prognostic value of PTN1 genes in 5 independent lung adenocarcinoma (ADC) and 5 lung independent squamous cell carcinoma (SCC) microarray datasets and found that the expression levels of PTN1 genes were associated with survival in lung ADC but not lung SCC. All of the lung ADC datasets contained a set of highly correlated genes from PTN1 genes, but the lung SCC datasets had no similar set of genes. We identified 63 unique core genes from the PTN1 genes in the 5 lung ADC datasets: 17 of these core genes appeared in at least 4 of the lung ADC datasets, and the 17 corresponding proteins clearly interacted more strongly with each other in lung ADC than in lung SCC. Moreover, 16 of the 17 core genes play major roles in the G2/M phase of the cell cycle. These data indicate that proliferation‐related genes in lung development have a significant prognostic value for lung ADC; the synergistic effects of the 17 core genes play an important role in lung ADC prognosis. These genes may have significant clinical implications for the treatment and prognosis of lung ADC.
登录
查看更多内容
影响因子：
3.7
作者：
Feng L;Wang J;Cao B;Zhang Y;Wu B;Di X;Jiang W;An N;Lu D;Gao S;Zhao Y;Chen Z;Mao Y;Gao Y;Zhou D;Jen J;Liu X;Zhang Y;Li X;Zhang K;He J;Cheng S
通讯作者：
Cheng S
影响因子：
5.3
作者：
O'Carroll, D;Erhardt, S;Jenuwein, T
通讯作者：
Jenuwein, T
影响因子：
7.5
作者：
Rodriguez-Pinilla, Socorro M.;Sarrio, David;Palacios, Jose
通讯作者：
Palacios, Jose
影响因子：
12.3
作者：
Naxerova K;Bult CJ;Peaston A;Fancher K;Knowles BB;Kasif S;Kohane IS
通讯作者：
Kohane IS
影响因子：
11.2
作者：
Dai, HY;van't Veer, L;Friend, S
通讯作者：
Friend, S