CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression.
CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression.
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CXCR4是通过调节VEGF表达抑制胃癌侵袭和迁移的预后标志物
DOI：
10.3892/ol.2021.12848
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发表时间：
2021-08
期刊：
影响因子：
2.9
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Chen G;Zhou Z;Jin J;Zhou Y;Liu Y;Wang W
转移是胃癌（GC）患者预后不良的主要原因。因此，当前的研究重点是确定可以预测GC患者预后的生物标志物。据报道，C-X-C 基序趋化因子受体 4 (CXCR4) 和血管内皮生长因子 (VEGF) 在不同类型的恶性肿瘤中发挥重要作用；然而，它们在GC预后中的作用仍不清楚。本研究旨在探讨CXCR4和VEGF在预测GC患者预后中的潜在作用。进行免疫组织化学分析以分析包含GC组织和邻近正常组织的GC组织微阵列中CXCR4和VEGF的表达水平。评估了 CXCR4 或 VEGF 表达水平与临床病理特征或生存结果之间的关联。此外，进行Transwell和伤口愈合测定以确定细胞的体外侵袭和迁移能力。结果表明CXCR4通过调节VEGF表达促进AGS细胞侵袭和迁移。此外，与邻近正常组织相比，GC组织中CXCR4和VEGF表达水平显着上调，这与较差的总生存期（OS）相关。 Cox 回归分析表明，CXCR4 和 VEGF 表达上调都是 OS 的独立阴性生物标志物。据我们所知，本研究首次发现CXCR4和VEGF作为GC患者的有效预后指标发挥协同作用。
Metastasis is the main cause of poor prognosis of patients with gastric cancer (GC). Thus, current research is focused on identifying biomarkers that can predict the prognosis of patients with GC. C-X-C motif chemokine receptor 4 (CXCR4) and vascular endothelial growth factor (VEGF) have been reported to play important roles in different types of malignancies; however, their role in the prognosis of GC remains unknown. The present study aimed to investigate the potential role of CXCR4 and VEGF in predicting the prognosis of patients with GC. Immunohistochemistry analysis was performed to analyze the expression levels of CXCR4 and VEGF in a GC tissue microarray containing GC tissues and adjacent normal tissues. The association between CXCR4 or VEGF expression levels and the clinicopathological characteristics or survival outcomes were assessed. Furthermore, Transwell and wound healing assays were performed to determine the cell invasive and migratory abilities in vitro. The results demonstrated that CXCR4 promoted AGS cell invasion and migration by regulating VEGF expression. In addition, CXCR4 and VEGF expression levels were significantly upregulated in GC tissues compared with adjacent normal tissues, which was associated with a poorer overall survival (OS). Cox regression analysis demonstrated that both upregulated CXCR4 and VEGF expression were independent negative biomarkers of OS. To the best of our knowledge, the present study was the first to discover that CXCR4 and VEGF exert synergistic roles as efficient prognostic indicators for patients with GC.
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影响因子：
3
作者：
Li, Heyan;Takayama, Koichi;Wang, Shuo;Shiraishi, Yoshimasa;Gotanda, Keisuke;Harada, Taishi;Furuyama, Kazuto;Iwama, Eiji;Ieiri, Ichiro;Okamoto, Isamu;Nakanishi, Yoichi
通讯作者：
Nakanishi, Yoichi
DOI：
10.1186/s13046-019-1461-z
发表时间：
2019-11-12
影响因子：
11.3
作者：
Baci, Denisa;Bruno, Antonino;Noonan, Douglas M.
通讯作者：
Noonan, Douglas M.
影响因子：
3.5
作者：
Naykoo, Niyaz A.;Dil-Afroze;Shah, Zafar A.
通讯作者：
Shah, Zafar A.
DOI：
10.31557/apjcp.2020.21.1.139
发表时间：
2020-01-01
期刊：
Asian Pacific journal of cancer prevention : APJCP
影响因子：
--
作者：
Albalawi, Ibrahim Altedlawi;Mir, Rashid;Abu Duhier, F M
通讯作者：
Abu Duhier, F M
影响因子：
2.6
作者：
Polkowska-Pruszynska, Beata;Rawicz-Pruszyniski, Karol;Polkowski, Wojciech P.
通讯作者：
Polkowski, Wojciech P.