Analysis of Genomic DNA from Medieval Plague Victims Suggests Long-Term Effect of Yersinia pestis on Human Immunity Genes.
Analysis of Genomic DNA from Medieval Plague Victims Suggests Long-Term Effect of Yersinia pestis on Human Immunity Genes.
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DOI：
10.1093/molbev/msab147
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发表时间：
2021-09-27
影响因子：
10.7
通讯作者：
Krause J
中科院分区：
文献类型：
--
作者：
Immel A;Key FM;Szolek A;Barquera R;Robinson MK;Harrison GF;Palmer WH;Spyrou MA;Susat J;Krause-Kyora B;Bos KI;Forrest S;Hernández-Zaragoza DI;Sauter J;Solloch U;Schmidt AH;Schuenemann VJ;Reiter E;Kairies MS;Weiß R;Arnold S;Wahl J;Hollenbach JA;Kohlbacher O;Herbig A;Norman PJ;Krause J
病原体和相关的传染病爆发对人类群体施加了选择性压力，由此导致的等位基因频率的任何变化可能对参与免疫的基因尤其明显。在这方面，1346-1353年由鼠疫耶尔森菌引起的黑死病大流行，持续数百年的鼠疫爆发，是人类历史上最具破坏性的记录之一。探讨Y.为了研究鼠疫对人体免疫基因的影响，我们从世纪德国埃尔万根的一个万人坑中的36名鼠疫受害者中提取了DNA。我们使用一种新的溶液杂交捕获方法靶向488个免疫相关基因，包括HLA。与埃尔万根的50名现代土著居民相比，我们发现先天免疫蛋白Ficolin-2和NLRP 14的变体在决定特异性的位点上的等位基因频率存在差异。我们还观察到，HLA-DRB 1 *13在现代人群中的频率是其两倍以上，而编码第80位异亮氨酸（I-80+）的HLA-B等位基因、编码第9位组氨酸的HLA-C *06：02和HLA-DPB 1等位基因在现代人群中的频率是其一半。模拟显示，自然选择可能驱动了这些等位基因频率的变化。因此，我们的数据表明，HLA基因的等位基因频率参与先天性和适应性免疫负责细胞外和细胞内的反应，致病菌，如Y。鼠疫，可能受到欧洲历史上流行病的影响。
Pathogens and associated outbreaks of infectious disease exert selective pressure on human populations, and any changes in allele frequencies that result may be especially evident for genes involved in immunity. In this regard, the 1346-1353 Yersinia pestis-caused Black Death pandemic, with continued plague outbreaks spanning several hundred years, is one of the most devastating recorded in human history. To investigate the potential impact of Y. pestis on human immunity genes, we extracted DNA from 36 plague victims buried in a mass grave in Ellwangen, Germany in the 16th century. We targeted 488 immune-related genes, including HLA, using a novel in-solution hybridization capture approach. In comparison with 50 modern native inhabitants of Ellwangen, we find differences in allele frequencies for variants of the innate immunity proteins Ficolin-2 and NLRP14 at sites involved in determining specificity. We also observed that HLA-DRB1*13 is more than twice as frequent in the modern population, whereas HLA-B alleles encoding an isoleucine at position 80 (I-80+), HLA C*06:02 and HLA-DPB1 alleles encoding histidine at position 9 are half as frequent in the modern population. Simulations show that natural selection has likely driven these allele frequency changes. Thus, our data suggest that allele frequencies of HLA genes involved in innate and adaptive immunity responsible for extracellular and intracellular responses to pathogenic bacteria, such as Y. pestis, could have been affected by the historical epidemics that occurred in Europe.
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影响因子：
64.8
作者：
Bos, Kirsten I.;Schuenemann, Verena J.;Golding, G. Brian;Burbano, Hernan A.;Waglechner, Nicholas;Coombes, Brian K.;McPhee, Joseph B.;DeWitte, Sharon N.;Meyer, Matthias;Schmedes, Sarah;Wood, James;Earn, David J. D.;Herring, D. Ann;Bauer, Peter;Poinar, Hendrik N.;Krause, Johannes
通讯作者：
Krause, Johannes
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1159/000019057
发表时间：
1998-01-01
期刊：
EXPERIMENTAL AND CLINICAL IMMUNOGENETICS
影响因子：
--
作者：
Darke, C;Guttridge, MG;Thomas, M
通讯作者：
Thomas, M
影响因子：
16.8
作者：
Boudreau JE;Hsu KC
通讯作者：
Hsu KC
影响因子：
64.8
作者：
Anand, Paras K.;Malireddi, R. K. Subbarao;Lukens, John R.;Vogel, Peter;Bertin, John;Lamkanfi, Mohamed;Kanneganti, Thirumala-Devi
通讯作者：
Kanneganti, Thirumala-Devi