Anti‐DNA Antibodies Induced by BK Virus Inoculations
Anti‐DNA Antibodies Induced by BK Virus Inoculations
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BK 病毒接种诱导的抗 DNA 抗体
DOI：
10.1111/j.1365-3083.1990.tb02910.x
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发表时间：
1990
影响因子：
3.7
通讯作者：
Ole Petter Rekvig
中科院分区：
文献类型：
--
作者：
K. Fredriksen;T. Traavik;Ole Petter Rekvig
The ability of BK virus to induce anti‐DNA antibodies in rabbits, and the ability of these antibodies to bind natural eukaryotic DNA and synthetic polynucleotides have been analysed. The specificity of the binding was assayed by inhibition of anti‐dsDNA and ‐ssDNA ELISA tests with dsDNA, ssDNA, and synthetic single‐stranded as well as double‐stranded polynucleotides The anti‐dsDNA activity of two rabbit antisera was effectively inhibited by dsDNA and ssDNA and poly(dAdT)‐poly(dAdT). The other nucleotide antigens produced relatively loss inhibition. The anti‐ssDNA binding was most efficiently inhibited by the homologous antigen, whereas inhibition by dsDNA only reached approximately 70%, of the maximum as defined by ssDNA as inhibitor. This indicates the existence of a selective anti‐ssDNA antibody population and, a population recognizing both ssDNA and dsDNA within the sera. Cross‐reaction of the induced anti‐DNA antibodies with phospholipid antigens, such as cardiolipin, phosphatidylic acid, and bacterial cell surface, could not be demonstrated We conclude that antibodies resulting from inoculation with BK virus specifically bind to dsDNA and ssDNA and possess a high affinity for the synthetic duplex poly (dAdT). In this way. they have some similarities with anti‐DNA antibodies encountered in SLE (systemic lupus erythematosus) in both man and mouse,
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人-人杂交瘤产生的单克隆狼疮自身抗体的多特异性。
DOI：
10.1056/nejm198302243080802
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
Shoenfeld,Y;Rauch,J;Massicotte,H;Datta,SK;Andre-Schwartz,J;Stollar,BD;Schwartz,RS
通讯作者：
Schwartz,RS
影响因子：
2.2
作者：
ZOUALI, M;STOLLAR, BD
通讯作者：
STOLLAR, BD
通过细菌 DNA 免疫在正常小鼠中诱导抗双链 DNA 抗体。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gilkeson,GS;Grudier,JP;Karounos,DG;Pisetsky,DS
通讯作者：
Pisetsky,DS
DNA 的免疫化学。
影响因子：
5
作者：
Stollar,BD
通讯作者：
Stollar,BD
正常受试者和系统性红斑狼疮患者血清中各种物种来源 DNA 抗体的自发表达。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Karounos,DG;Grudier,JP;Pisetsky,DS
通讯作者：
Pisetsky,DS