Paracrine functions of fibrocytes to promote lung fibrosis.
Paracrine functions of fibrocytes to promote lung fibrosis.
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DOI：
10.1586/17476348.2014.862154
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发表时间：
2014-04
影响因子：
3.9
通讯作者：
Kim KK
中科院分区：
文献类型：
--
作者：
Kleaveland KR;Moore BB;Kim KK
Fibrocytes derive from the bone marrow and are found in the circulation. They can be recruited to sites of injury and contribute to repair/remodeling. In vitro evidence suggests that fibrocytes may differentiate into fibroblasts to promote lung fibrosis. However, in vivo evidence for this is sparse. This review summarizes recent literature which may suggest that fibrocytes function to promote fibrosis via paracrine actions. In this way, secretion of growth factors, proteases and matricellular proteins may strongly influence the actions of resident epithelial and mesenchymal cells to promote repair and resolution or to tip the scale towards pathologic remodeling.
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