Why Innate Lymphoid Cells?
Why Innate Lymphoid Cells?
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DOI：
10.1016/j.immuni.2018.06.002
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发表时间：
2018-06-19
期刊：
影响因子：
32.4
通讯作者：
Locksley RM
中科院分区：
文献类型：
--
作者：
Kotas ME;Locksley RM
Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express receptors responsive to their organ microenvironments, and perform an arsenal of effector functions that overlap those of adaptive CD4+ T cells. Based on knowledge regarding subsets of invariant-like lymphocytes (e.g.; γδ T cells, MAIT cells, etc) and fetally-derived macrophages, we hypothesize that immune cells established during the perinatal period—including, but not limited to ILCs— serve intimate roles in tissue that go beyond classical understanding of the immune system in microbial host defense. In this perspective, we propose mechanisms by which the establishment of ILCs and the tissue lymphoid niche during early development may have consequences much later in life. Although definitive answers require better tools, efforts to achieve deeper understanding of ILC biology across the mammalian lifespan have the potential to lift the veil on the unknown breadth of immune cell functions.
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