Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
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DOI：
10.1016/j.amjcard.2008.10.011
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发表时间：
2009-02-15
影响因子：
2.8
通讯作者：
Shi, Guo-Ping
中科院分区：
文献类型：
--
作者：
Liu, Yingxian;Li, Xiangping;Peng, Daoquan;Tan, Zheng;Liu, Hongmin;Qing, Yingnan;Xue, Yanqiong;Shi, Guo-Ping
在人类动脉粥样硬化病变中检测到的半胱氨酰组织蛋白酶L水平高于健康动脉粥样硬化。然而，人类冠心病（CHD）和系统性组织蛋白酶L水平之间的联系仍然未知。共有137名志愿者被诊断为急性和既往心肌梗死（MI）和稳定型和不稳定型心绞痛，除了48名对照组被要求进行冠状动脉造影。测量血清组织蛋白酶L、高敏C反应蛋白、空腹血糖和脂蛋白谱。冠心病组血清组织蛋白酶L水平明显高于非冠心病组（P <0.001）。在调整了大多数主要混杂因素后，该显著性仍然存在。不稳定型心绞痛患者血清组织蛋白酶L水平高于稳定型心绞痛患者（p = 0.02）。急性冠状动脉综合征患者中，急性心肌梗死患者血清组织蛋白酶L水平高于不稳定型心绞痛患者（p <0.05），既往心肌梗死患者血清组织蛋白酶L水平最高。重要的是，血清组织蛋白酶L与冠状动脉分支管腔扩张的数量呈正相关（R = 0.38，p <0.001），Gensini评分（R = 0.44，p <0.001），高敏C反应蛋白（R = 0.32，p <0.001），空腹血糖（R = 0.16，p <0.03），吸烟者（R = 0.27，p <0.001），但与高密度脂蛋白（R =-0.23，p = 0.002）和载脂蛋白A1（R =-0.19，p = 0.01）呈负相关。总之，在调整这些混杂因素后，我们发现血清组织蛋白酶L与Gensini评分呈正相关且独立，表明血清组织蛋白酶L可作为CHD的一种新的独立生物标志物。
Higher levels of cysteinyl cathepsin L were detected in human atherosclerotic lesions than in healthy aortas. However, a link between human coronary heart disease (CHD) and systemic cathepsin L levels remains unknown. A total of 137 volunteers with diagnosed acute and previous myocardial infarction (MI) and stable and unstable angina pectoris in addition to 48 controls were asked to undergo coronary angiography. Serum cathepsin L, high-sensitivity C-reactive protein, fasting glucose, and lipid protein profiles were measured. Serum cathepsin L levels were significantly higher in patients with CHD than in those without CHD (p <0.001). The significance persisted after adjusting for most major confounders. Patients with unstable angina pectoris had higher serum cathepsin L levels than those with stable angina pectoris (p = 0.02). Of patients with acute coronary syndrome, those with acute MI had higher serum cathepsin L levels than those with unstable angina pectoris (p <0.05) and patients with previous MI had the highest levels. Importantly, serum cathepsin L associated positively with number of coronary branch luminal narrowings (R = 0.38, p <0.001), Gensini scores (R = 0.44, p <0.001), high-sensitivity C-reactive protein (R = 0.32, p <0.001), fasting glucose (R = 0.16, p <0.03), and cigarette smokers (R = 0.27, p <0.001), but inversely with high-density lipoprotein (R = -0.23, p = 0.002) and apolipoprotein A1 (R = -0.19, p = 0.01) in all subjects. In conclusion, after adjusting for these confounders, we found that serum cathepsin L correlated positively and independently with Gensini score, suggesting that serum cathepsin L serves as a novel and independent biomarker for CHD.
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影响因子：
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