The meaning of mitochondrial movement to a neuron's life.
The meaning of mitochondrial movement to a neuron's life.
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DOI:
10.1016/j.bbamcr.2012.04.007
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发表时间:
2013-01
期刊:
影响因子:
--
通讯作者:
Wang X
中科院分区:
文献类型:
--
作者:
Lovas JR;Wang X
Cells precisely regulate mitochondrial movement in order to balance energy needs and avoid cell death. Neurons are particularly susceptible to disturbance of mitochondrial motility and distribution due to their highly extended structures and specialized function. Regulation of mitochondrial motility plays a vital role in neuronal health and death. Here we review the current understanding of regulatory mechanisms that govern neuronal mitochondrial transport and probe their implication in health and disease.
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