False-positive elevations of carcinoembryonic antigen in patients with a history of resected colorectal cancer.
False-positive elevations of carcinoembryonic antigen in patients with a history of resected colorectal cancer.
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DOI：
10.6004/jnccn.2014.0085
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Saltz L
中科院分区：
文献类型：
--
作者：
Litvak A;Cercek A;Segal N;Reidy-Lagunes D;Stadler ZK;Yaeger RD;Kemeny NE;Weiser MR;Pessin MS;Saltz L
常规监测癌胚抗原（CEA）水平是切除的结直肠癌（CRC）患者的标准。假阳性的发生率和假阳性升高的上限以前没有得到很好的表征。对纪念斯隆-凯特琳癌症中心的医疗记录进行了检索，确定了728名在2003年1月至2012年12月期间接受局部CRC R 0切除术的患者，这些患者在正常围手术期CEA水平后CEA水平升高超过正常范围。其中，358例患者的CEA水平呈假阳性升高，335例患者的CEA水平呈真阳性升高，表明CRC复发，35例患者的CEA水平呈真阳性升高，表明出现了新的非CRC恶性肿瘤。在假性升高的患者中，111例有单一孤立的CEA水平升高（中位数最高CEA水平为5.5 ng/mL），无进一步异常测量，而247例有2次或2次以上读数升高，中位数最高水平为6.7 ng/mL。在这247例确认假阳性CEA水平升高的患者中，仅5例（2%）测量值大于15 ng/mL，并且没有确认升高大于35 ng/mL为假阳性。假阳性CEA测试结果在5至15 ng/mL的范围内是常见的。在开始影像学检查之前确认CEA升高在此范围内可能是合适的。大于15 ng/mL的假阳性结果很少见，所有确认的CEA水平大于35 ng/mL都与癌症复发相关。
Routine monitoring of carcinoembryonic antigen (CEA) levels is standard in patients with resected colorectal cancer (CRC). The incidence of false-positives and the upper limits of false-positive elevations have not been previously well characterized. A search of medical records at Memorial Sloan-Kettering Cancer Center identified 728 patients who underwent an R0 resection of locoregional CRC between January 2003 and December 2012 and who had an increase in CEA level above the normal range after a normal perioperative CEA level. Of these, 358 had a false-positive elevation of CEA level, 335 had a true-positive elevation indicative of recurrent CRC, and 35 had a true-positive elevation indicative of the development of a new, non-CRC malignancy. Of those with false elevations, 111 had a single isolated CEA level elevation (median highest CEA level of 5.5 ng/mL) with no further abnormal measurements, whereas 247 had elevations on 2 or more readings, with a median highest level of 6.7 ng/mL. Of these 247 patients with confirmed false-positive CEA level elevations, only 5 (2%) had measurements greater than 15 ng/mL, and no confirmed elevation greater than 35 ng/mL was a false-positive. False-positive CEA test results in the range of 5 to 15 ng/mL are common. Confirmation of CEA elevation in this range before initiating imaging studies may be appropriate. False-positive results greater than 15 ng/mL are rare, and all confirmed CEA levels greater than 35 ng/mL were associated with cancer recurrence.
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DOI：
10.1073/pnas.64.1.161
发表时间：
1969-01-01
影响因子：
11.1
作者：
THOMSON, DMP;KRUPEY, J;GOLD, P
通讯作者：
GOLD, P
DOI：
10.1084/jem.122.3.467
发表时间：
1965-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gold P;Freedman SO
通讯作者：
Freedman SO
影响因子：
6.2
作者：
CONCANNON, JP;DALBOW, MH;LIEBLER, GA
通讯作者：
LIEBLER, GA
影响因子：
4.8
作者：
Thomas, Susan N.;Zhu, Fei;Konstantopoulos, Konstantinos
通讯作者：
Konstantopoulos, Konstantinos
影响因子：
120.7
作者：
MOERTEL, CG;FLEMING, TR;TANGEN, C
通讯作者：
TANGEN, C