Nanobioimaging and sensing of infectious diseases.
Nanobioimaging and sensing of infectious diseases.
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DOI：
10.1016/j.addr.2009.11.014
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发表时间：
2010-03-18
影响因子：
16.1
通讯作者：
Santra S
中科院分区：
文献类型：
--
作者：
Tallury P;Malhotra A;Byrne LM;Santra S
快速、准确和高灵敏度地识别痕量传染性病原体的新方法是预防流行病和生命损失的持续需求。早期发现这些病原体以预防、治疗和遏制感染的传播至关重要。因此，需要和迫切需要灵敏、特异、准确、易于使用的诊断测试。多功能的生物功能化工程纳米材料被证明是有前途的，在满足这些需求，在诊断食品，血液和临床样品中的病原体。纳米材料独特的光学和磁性特性已被用于诊断。本文综述了荧光纳米粒子、金属纳米结构和超顺磁性纳米粒子在感染性微生物生物成像和检测中的应用。介绍了为在体外和体内对溶液、食品或生物样品中的传染性病毒和细菌进行成像、检测和捕获而开发的各种纳米诊断分析方法，并讨论了它们与发展中国家的相关性。
New methods to identify trace amount of infectious pathogens rapidly, accurately and with high sensitivity are in constant demand to prevent epidemics and loss of lives. Early detection of these pathogens to prevent, treat and contain the spread of infections is crucial. Therefore, there is a need and urgency for sensitive, specific, accurate, easy-to-use diagnostic tests. Versatile biofunctionalized engineered nanomaterials are proving to be promising in meeting these needs in diagnosing the pathogens in food, blood and clinical samples. The unique optical and magnetic properties of the nanoscale materials have been put to use for the diagnostics. In this review, we focus on the developments of the fluorescent nanoparticles, metallic nanostructures and superparamagnetic nanoparticles for bioimaging and detection of infectious microorganisms. The various nanodiagnostic assays developed to image, detect and capture infectious virus and bacteria in solutions, food or biological samples in vitro and in vivo are presented and their relevance to developing countries is discussed.
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影响因子：
3.7
作者：
Duan, LL;Wang, YF;Li, SSC;Wan, ZX;Zhai, JX
通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0601211103
发表时间：
2006-03-28
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
7.4
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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