Cell-trappable fluorescent probes for nitric oxide visualization in living cells.

Cell-trappable fluorescent probes for nitric oxide visualization in living cells.
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DOI:
10.1021/ol1006289
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发表时间:
2010-05-21
期刊:
影响因子:
5.2
通讯作者:
Lippard SJ
Lippard SJ
中科院分区:
化学1区
文献类型:
--
作者:
Pluth MD;McQuade LE;Lippard SJ

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Two new cell-trappable fluorescent probes for nitric oxide (NO) are reported based on either incorporation of hydrolyzable esters or conjugation to aminodextran polymers. Both probes are highly selective for NO over other reactive oxygen and nitrogen species (RONS). The efficacy of these probes for the fluorescence imaging of nitric oxide produced endogenously in Raw 264.7 cells is demonstrated.
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