Senescence and programmed cell death in plants: polyamine action mediated by transglutaminase.
Senescence and programmed cell death in plants: polyamine action mediated by transglutaminase.
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植物的衰老和程序性细胞死亡：转谷氨酰胺酶介导的多胺作用。
DOI：
10.3389/fpls.2014.00120
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发表时间：
2014
影响因子：
5.6
通讯作者：
Cai G
中科院分区：
文献类型：
--
作者：
Del Duca S;Serafini-Fracassini D;Cai G
植物中的多胺(Pas)研究历时50多年，发现了这些脂肪族阳离子的许多作用。Pas调节细胞的分裂、分化、器官发生、生殖、休眠-打破和衰老，以及对外界刺激和胁迫的稳态调节。然而，其多重活性的分子机制仍有待研究。Pas以自由和结合的形式存在，并与几个重要的细胞分子相互作用；其中一些相互作用可能是通过转谷氨酰胺酶(TGase)催化的共价键发生的，从而引起特定蛋白质之间的阳离子作用或交联键。PAS可以延缓衰老和程序性细胞死亡(PCD)；为了重新解释其中的一些影响并获得对其分子机制的新见解，本文对它们的结合进行了修改。TGase介导的蛋白质与Pas之间的相互作用是本综述的主要目标。在介绍了TGase的特性及其在动物PCD中的催化和作用后，介绍了研究TGase的植物衰老和PCD模型：自然衰老或切花的花冠，切花或不切花的叶片衰老，自交不亲和授粉期间的花粉，超敏反应和休眠解除期间的块茎贮藏薄壁组织。在所有被检测的模型中，TGase似乎参与了与动物细胞凋亡过程中描述的相似的分子机制，尽管几种底物是不同的。其作用可能与PCD的类型有关，但更多的是为了实现特定的PCD方案而对底物进行修饰。作为Pas和蛋白质的交联物，TGase在Pas在衰老和PCD中的多种作用中发挥着重要的作用，有时也是有争议的。
Research on polyamines (PAs) in plants laps a long way of about 50 years and many roles have been discovered for these aliphatic cations. PAs regulate cell division, differentiation, organogenesis, reproduction, dormancy-break and senescence, homeostatic adjustments in response to external stimuli and stresses. Nevertheless, the molecular mechanisms of their multiple activities are still matter of research. PAs are present in free and bound forms and interact with several important cell molecules; some of these interactions may occur by covalent linkages catalyzed by transglutaminase (TGase), giving rise to “cationization” or cross-links among specific proteins. Senescence and programmed cell death (PCD) can be delayed by PAs; in order to re-interpret some of these effects and to obtain new insights into their molecular mechanisms, their conjugation has been revised here. The TGase-mediated interactions between proteins and PAs are the main target of this review. After an introduction on the characteristics of this enzyme, on its catalysis and role in PCD in animals, the plant senescence and PCD models in which TGase has been studied, are presented: the corolla of naturally senescing or excised flowers, the leaves senescing, either excised or not, the pollen during self-incompatible pollination, the hypersensitive response and the tuber storage parenchyma during dormancy release. In all the models examined, TGase appears to be involved by a similar molecular mechanism as described during apoptosis in animal cells, even though several substrates are different. Its effect is probably related to the type of PCD, but mostly to the substrate to be modified in order to achieve the specific PCD program. As a cross-linker of PAs and proteins, TGase is an important factor involved in multiple, sometimes controversial, roles of PAs during senescence and PCD.
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影响因子：
3.5
作者：
Del Duca, S.;Cai, G.;Serafini-Fracassini, D.
通讯作者：
Serafini-Fracassini, D.
影响因子：
6.4
作者：
Del Duca, Stefano;Betti, Lucietta;Torrigiani, Patrizia
通讯作者：
Torrigiani, Patrizia
DOI：
10.1016/1011-1344(95)07240-3
发表时间：
1996-04-01
影响因子：
5.4
作者：
Andreadakis, A;Kotzabasis, K
通讯作者：
Kotzabasis, K
影响因子：
3.5
作者：
COHEN, SS;MARCU, DE;BALINT, RF
通讯作者：
BALINT, RF
影响因子：
3.9
作者：
Campos, A.;Carvajal-Vallejos, P. K.;Santos, M.
通讯作者：
Santos, M.