Lipid droplets go through a (liquid crystalline) phase.

Lipid droplets go through a (liquid crystalline) phase.
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DOI:
10.1083/jcb.202210008
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发表时间:
2022-11-07
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
--
中科院分区:
其他
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Windham和Cohen预览了Rogers等人的工作,表明甘油三酯脂解促进脂滴(LD)的液晶相变以及LD蛋白质组的变化。脂滴是脂肪储存和运输的关键细胞器。本期Rogers et al. (2022.)[j]细胞生物学。https://doi.org/10.1083/jcb.202205053)表明葡萄糖限制会触发LD内的液晶晶格形成,进而改变LD表面蛋白质的募集。
Windham and Cohen preview work from Rogers et al. showing that triglyceride lipolysis promotes liquid crystalline phase transitions in lipid droplets (LDs) as well as changes in the LD proteome. Lipid droplets (LDs) are key organelles for fat storage and trafficking. In this issue, Rogers et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202205053) show that glucose restriction triggers liquid crystalline lattice formation within LDs, which in turn alters the recruitment of proteins to the LD surface.
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