Total-Body PET Imaging of Musculoskeletal Disorders.

Total-Body PET Imaging of Musculoskeletal Disorders.
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DOI:
10.1016/j.cpet.2020.09.012
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发表时间:
2021-01
期刊:
影响因子:
2.6
通讯作者:
Alavi A
Alavi A
中科院分区:
其他
文献类型:
--
作者:
Chaudhari AJ;Raynor WY;Gholamrezanezhad A;Werner TJ;Rajapakse CS;Alavi A

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肌肉骨骼疾病(MSD)被广泛定义为关节、骨骼、肌肉、神经、肌腱、韧带、支持软组织、软骨和椎间盘的疾病或损伤,包括150多种诊断。1常见的例子是关节炎(如类风湿性关节炎、系统性红斑狼疮或骨关节炎)、骨质疏松/骨质减少、肌肉减少、感染、肿瘤以及颈部和下背部疼痛。MSD是全世界残疾的主要原因,仅次于精神和药物使用障碍,2并对全球人口健康产生重大负面影响。它们在整个生命周期中普遍存在,并具有天文数字的社会成本,其形式为有限的流动性,灵活性和功能能力,持续性疼痛,无法工作,提前退休,无法参与社会角色,抑郁症以及发展其他慢性疾病的风险增加。3
Musculoskeletal disorders (MSDs) are broadly defined as diseases or injuries of the joints, bones, muscles, nerves, tendons, ligaments, supporting soft tissues, cartilage, and spinal discs, and comprise over 150 diagnoses. 1 Commonly encountered examples are arthritis (such as rheumatoid arthritis, systemic lupus erythematous, or osteoarthritis), osteoporosis/osteopenia, sarcopenia, infection, neoplasms, and neck and lower back pain. MSDs are a major cause of disability worldwide, second only to mental and substance use disorders, 2 and have a significant negative impact on global population health. They are prevalent across the lifespan and have an astronomical societal cost that comes in the form of limited mobility, dexterity and functional ability, persistent pain, inability to work, early retirement from work, inability to participate in societal roles, depression, and increased risk of developing other chronic disease conditions. 3
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