Effects of smoking abstinence, smoking cues and nicotine replacement in smokers with schizophrenia and controls.

Effects of smoking abstinence, smoking cues and nicotine replacement in smokers with schizophrenia and controls.
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戒烟、吸烟线索和尼古丁替代对精神分裂症吸烟者和对照组的影响。

DOI:
10.1080/14622200802097373
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发表时间:
2008
期刊:
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子:
--
通讯作者:
Adolfo,AmyB
Adolfo,AmyB
中科院分区:
--
文献类型:
--
作者:
Tidey,JenniferW;Rohsenow,DamarisJ;Kaplan,GaryB;Swift,RobertM;Adolfo,AmyB

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The mechanisms underlying the low smoking cessation rates among smokers with schizophrenia (SS) are unknown. In this laboratory study, we compared the responses of 21 SS and 21 non-psychiatric controls (CS) to manipulations of 5-hour smoking abstinence, transdermal nicotine replacement (0mg, 21mg and 42mg), andin vivosmoking cues. Results indicate that SS were more sensitive than CS to the effects of acute abstinence on carbon monoxide (CO) boost, but not more sensitive to the effects of abstinence on urge levels or withdrawal symptoms. SS and CS did not differ in urge response toin vivosmoking cues, but SS were less consistent in their reactions. These findings suggest that heightened sensitivity to the effects of abstinence on smoke intake may partially account for the low cessation rates experienced by SS, but other potential mechanisms should be explored using behavioral laboratory models.
第二版
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