Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New diagnostic criteria of fulminant type 1 diabetes mellitus (2012).

Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New diagnostic criteria of fulminant type 1 diabetes mellitus (2012).
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DOI:
10.1111/jdi.12024
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发表时间:
2012-12-20
影响因子:
3.2
通讯作者:
Maruyama T
Maruyama T
中科院分区:
医学3区
文献类型:
--
作者:
Imagawa A;Hanafusa T;Awata T;Ikegami H;Uchigata Y;Osawa H;Kawasaki E;Kawabata Y;Kobayashi T;Shimada A;Shimizu I;Takahashi K;Nagata M;Makino H;Maruyama T

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我们修订了暴发型1型糖尿病诊断标准的一部分。新的标准既表达了本病患者血糖快速升高的本质,又具有高度的敏感性,以减少误诊。通过对382例新诊断的暴发型1型糖尿病患者资料的分析,采用糖化血红蛋白(HbA1c)为8.7%(国家糖化血红蛋白标准化计划[NGSP]值)。通过对接收器工作特性曲线的分析,表明新判据具有100%的灵敏度和最佳值。此外,我们在新的标准中增加了一条评论,即“这个值(在NGSP中为8.7%HbA1c<)不适用于以前诊断为糖耐量异常的患者”,还添加了一条评论,作为相关发现报告了“与人类白细胞抗原DRB1*04:05-DQB1*04:01的相关性”。我们没有修改筛查标准和诊断标准的其他部分,因为它们仍然是可靠的。
We have revised a part of the diagnostic criteria for fulminant type 1 diabetes. The new criteria were set both to express the essence of this disease of rapid increase of patients' blood glucose and to be highly sensitive to reduce the misdiagnosis. After analyzing the data of 382 patients with newly‐diagnosed fulminant type 1 diabetes, we adopted the glycated hemoglobin (HbA1c) level of 8.7% (National Glycohemoglobin Standardization Program [NGSP] value). The new criterion indicates 100% of sensitivity and the best value by receiver operating characteristic curve analysis. In addition, we added a comment that ‘This value (HbA1c <8.7% in NGSP) is not applicable for patients with previously diagnosed glucose intolerance’ in the new criteria and also a comment that ‘Association with human leukocyte antigen DRB1*04:05‐DQB1*04:01 is reported’ as a related finding. We did not revise the screening criteria and the other part of the diagnostic criteria, because they are still reliable.
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