Developmental changes in renal tubular transport-an overview.
Developmental changes in renal tubular transport-an overview.
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DOI：
10.1007/s00467-013-2666-6
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发表时间：
2015-12
影响因子：
3
通讯作者：
Baum, Michel
中科院分区：
文献类型：
--
作者：
Gattineni, Jyothsna;Baum, Michel
尽管水和盐的摄入量发生变化，成人肾脏仍保持恒定的细胞外液体积和组成。新生儿出生时肾脏的肾小球滤过率只有成年人的一小部分，未成熟的肾小管的功能比成年动物的低。尽管如此，新生儿也能够保持恒定的细胞外液体积和组成。出生后肾小管的发育曾被认为是由于转运蛋白丰度的增加，以满足肾小球滤过率的发育增加。然而，生后肾脏各节段的发育是相当复杂的。存在几种转运蛋白的亚型变化以及影响肾小管重吸收溶质和水的能力的信号转导的发育变化。这篇综述将讨论新生儿肾小管功能的差异，已被发现的新生儿和成人之间的重点。我们还将讨论一些因素，负责在出生后肾脏发育过程中发生的肾小管运输的成熟变化。
The adult kidney maintains a constant volume and composition of extracellular fluid despite changes in water and salt intake. The neonate is born with a kidney that has a small fraction of the glomerular filtration rate of the adult and immature tubules that function at a lower capacity than that of the mature animal. None the less, the neonate is also able to maintain a constant extracellular fluid volume and composition. Postnatal renal tubular development was once thought to be due to an increase in the transporter abundance to meet the developmental increase in glomerular filtration rate. However, postnatal renal development of each nephron segment is quite complex. There are isoform changes of several transporters as well as developmental changes in signal transduction that affect the capacity of renal tubules to reabsorb solutes and water. This review will discuss neonatal tubular function with an emphasis on the differences that have been found between the neonate and adult. We will also discuss some of the factors that are responsible for the maturational changes in tubular transport that occur during postnatal renal development.
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影响因子：
--
作者：
BAUM, M;QUIGLEY, R
通讯作者：
QUIGLEY, R
影响因子：
4.1
作者：
AMMAR, A;ROSEAU, S;BUTLEN, D
通讯作者：
BUTLEN, D
DOI：
10.1111/j.1651-2227.1984.tb17764.x
发表时间：
1984-01-01
期刊：
ACTA PAEDIATRICA SCANDINAVICA
影响因子：
--
作者：
APERIA, A;HERIN, P;ZETTERSTROM, R
通讯作者：
ZETTERSTROM, R
影响因子：
--
作者：
APERIA, A;LARSSON, L;ZETTERSTROM, R
通讯作者：
ZETTERSTROM, R
DOI：
10.1152/ajpregu.00257.2005
发表时间：
2005-12-01
影响因子：
2.8
作者：
Baum, M;Quigley, R
通讯作者：
Quigley, R